1-methyl-3-oxo-2-phenethyl-cyclohexanecarboxylic acid methyl ester

Base Information

• Chemical Name: 1-methyl-3-oxo-2-phenethyl-cyclohexanecarboxylic acid methyl ester
• CAS No.: 55732-04-2
• Molecular Formula: C₁₇H₂₂O₃
• Molecular Weight: 274.36
• Mol file: 55732-04-2.mol

Synonyms:1-methyl-3-oxo-2-phenethyl-cyclohexanecarboxylic acid methyl ester

Chemical Property of 1-methyl-3-oxo-2-phenethyl-cyclohexanecarboxylic acid methyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 1-methyl-3-oxo-2-phenethyl-cyclohexanecarboxylic acid methyl ester

There total 2 articles about 1-methyl-3-oxo-2-phenethyl-cyclohexanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methyl-2-(2-phenylethyl)cyclohex-2-en-1-one (56268-58-7) → 1-methyl-3-oxo-2-phenethyl-cyclohexanecarboxylic acid methyl ester (55732-04-2)

Guidance literature:

With hydrogen cyanide; Reaktion ueber mehrere Stufen;

DOI:10.1021/ja01492a048 DOI:10.1016/S0040-4039(00)70286-3

Reference yield:

methanol (67-56-1) + 3-methyl-2-(2-phenylethyl)cyclohex-2-en-1-one (56268-58-7) + potassium cyanide (151-50-8) → 1-methyl-3-oxo-2-phenethyl-cyclohexanecarboxylic acid methyl ester (55732-04-2)

Guidance literature:

Multistep reaction; (i) /BRN= 4652394/, (ii) aq. KOH, (iii) /BRN= 1098229/, H₂SO₄;

DOI:10.1021/ja01492a048

Reference yield:

1-methyl-3-oxo-2-phenethyl-cyclohexanecarboxylic acid methyl ester (55732-04-2) → 1-methylphenanthrene (832-69-9)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂SO₄

2: aq. KOH / ethane-1,2-diol

3: Pd-C / 280 - 290 °C

With potassium hydroxide; sulfuric acid; palladium on activated charcoal; In ethylene glycol;

DOI:10.1021/jo01264a003

upstream raw materials:

3-methyl-2-(2-phenylethyl)cyclohex-2-en-1-one

methanol

potassium cyanide

Downstream raw materials:

1,4a-Dimethyl-1-carboxy-1,2,3,4,4a,9,10,10a-octahydro-phenanthren

1,4aβ-dimethyl-1,2,3,4,4a,9,10,10aα-octahydrophenanthrene-1β-carboxylic acid

1-methylphenanthrene

(+/-)-1t-methyl-(4arH.10atH)-1.2.3.4.4a.9.10.10a-octahydro-phenanthrene-carboxylic acid-(1c)-methyl ester