Carbonic acid (2R,3S,5R)-5-(4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester 3-trifluoromethyl-phenyl ester

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Chemical Name:Carbonic acid (2R,3S,5R)-5-(4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester 3-trifluoromethyl-phenyl ester
CAS No.:630109-91-0
Molecular Formula:C₃₈H₃₄F₃N₃O₈
Molecular Weight:717.698
Hs Code.:

Carbonic acid (2R,3S,5R)-5-(4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester 3-trifluoromethyl-phenyl ester

Synonyms:Carbonic acid (2R,3S,5R)-5-(4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester 3-trifluoromethyl-phenyl ester

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Chemical Property of Carbonic acid (2R,3S,5R)-5-(4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester 3-trifluoromethyl-phenyl ester

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Technology Process of Carbonic acid (2R,3S,5R)-5-(4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester 3-trifluoromethyl-phenyl ester

There total 4 articles about Carbonic acid (2R,3S,5R)-5-(4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester 3-trifluoromethyl-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.1%

: 212832-35-4
N⁴-dimethoxytrityl-2'-deoxycytidine

: 95668-29-4
3-(trifluoromethyl)phenyl carbonochloridate

: 630109-91-0
Carbonic acid (2R,3S,5R)-5-(4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester 3-trifluoromethyl-phenyl ester

Guidance literature:: With pyridine; at 20 ℃;
DOI:10.1021/ja030376n

Reference yield:

: 102434-71-9
2'-deoxy-3',5'-di-O-1,1,3,3-(tetraisopropyldisiloxane-1,3-diyl)cytidine

: 630109-91-0
Carbonic acid (2R,3S,5R)-5-(4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester 3-trifluoromethyl-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 20 °C

2: TEMED; aq. HF / acetonitrile / 2.5 h

3: 73.1 percent / pyridine / 20 °C

With pyridine; N,N,N,N,-tetramethylethylenediamine; hydrogen fluoride; In acetonitrile;
DOI:10.1021/ja030376n

Reference yield:

: 951-77-9
2'-Deoxycytidine

: 630109-91-0
Carbonic acid (2R,3S,5R)-5-(4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester 3-trifluoromethyl-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 99.9 percent / pyridine / 20 °C

2: pyridine / 20 °C

3: TEMED; aq. HF / acetonitrile / 2.5 h

4: 73.1 percent / pyridine / 20 °C

With pyridine; N,N,N,N,-tetramethylethylenediamine; hydrogen fluoride; In acetonitrile;
DOI:10.1021/ja030376n