2-{[1-Phenyl-meth-(E)-ylidene]-amino}-pent-4-enoic acid ethyl ester

Base Information

• Chemical Name: 2-{[1-Phenyl-meth-(E)-ylidene]-amino}-pent-4-enoic acid ethyl ester
• CAS No.: 119933-90-3
• Molecular Formula: C₁₄H₁₇NO₂
• Molecular Weight: 231.294
• Mol file: 119933-90-3.mol

Synonyms:2-{[1-Phenyl-meth-(E)-ylidene]-amino}-pent-4-enoic acid ethyl ester

Chemical Property of 2-{[1-Phenyl-meth-(E)-ylidene]-amino}-pent-4-enoic acid ethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-{[1-Phenyl-meth-(E)-ylidene]-amino}-pent-4-enoic acid ethyl ester

There total 2 articles about 2-{[1-Phenyl-meth-(E)-ylidene]-amino}-pent-4-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

ethyl N-benzylideneglycinate (40682-54-0) + allyl bromide (106-95-6) → 2-{[1-Phenyl-meth-(E)-ylidene]-amino}-pent-4-enoic acid ethyl ester (119933-90-3)

Guidance literature:

With potassium hydroxide; potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride; In acetonitrile; for 14h; Ambient temperature;

DOI:10.1016/S0040-4020(01)86041-5

Reference yield:

glyoxylic acid ethyl ester (924-44-7) + 1-phenyl-but-3-enylamine (4383-23-7) → 2-{[1-Phenyl-meth-(E)-ylidene]-amino}-pent-4-enoic acid ethyl ester (119933-90-3)

Guidance literature:

In toluene; for 2h; Molecular sieve; Reflux; Inert atmosphere;

DOI:10.1021/ol101606v

Reference yield:

2-{[1-Phenyl-meth-(E)-ylidene]-amino}-pent-4-enoic acid ethyl ester (119933-90-3) → rac-allylglycine (1069-48-3,7685-44-1)

Guidance literature:

With hydrogenchloride; Yield given. Multistep reaction; 1.) ether, 12 h, room temp.; 2.) reflux, 4 h;

DOI:10.1016/S0040-4020(01)86041-5

upstream raw materials:

ethyl N-benzylideneglycinate

allyl bromide

glyoxylic acid ethyl ester

1-phenyl-but-3-enylamine

Downstream raw materials:

rac-allylglycine