([1-PHENYL-METH-(E)-YLIDENE]-AMINO)-ACETIC ACID ETHYL ESTER

Base Information

• Chemical Name: ([1-PHENYL-METH-(E)-YLIDENE]-AMINO)-ACETIC ACID ETHYL ESTER
• CAS No.: 40682-54-0
• Molecular Formula: C11H13 N O2
• Molecular Weight: 191.23
• Hs Code.: 2925290090
• Mol file: 40682-54-0.mol

Synonyms:Glycine,N-benzylidene-, ethyl ester (7CI); Benzylideneglycine ethyl ester; Ethyl(benzylideneamino)acetate; Ethyl N-benzylideneglycinate; N-Benzylideneglycineethyl ester; NSC 617266

Chemical Property of ([1-PHENYL-METH-(E)-YLIDENE]-AMINO)-ACETIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 0.00551mmHg at 25°C
• Refractive Index: 1.503
• Boiling Point: 274.1°C at 760 mmHg
• Flash Point: 113.9°C
• PSA: 38.66000
• Density: 1.01g/cm³
• LogP: 1.66860

Purity/Quality:

98%min ^*data from raw suppliers

N-BenzylideneglycineEthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ([1-PHENYL-METH-(E)-YLIDENE]-AMINO)-ACETIC ACID ETHYL ESTER

There total 7 articles about ([1-PHENYL-METH-(E)-YLIDENE]-AMINO)-ACETIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzaldehyde (100-52-7) + GlyOEt*HCl (459-73-4) → ethyl N-benzylideneglycinate (40682-54-0)

Guidance literature:

With magnesium sulfate; In dichloromethane; at 20 ℃;

DOI:10.1080/00397910802621723

Reference yield: 100.0%

glycine ethyl ester hydrochloride (623-33-6) + benzaldehyde (100-52-7) → ethyl N-benzylideneglycinate (40682-54-0)

Guidance literature:

glycine ethyl ester hydrochloride; With ammonia; In dichloromethane; water;

benzaldehyde; With magnesium sulfate; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.5b00320

Reference yield:

ethyl 2-aminoacetate hydrochloride + benzaldehyde (100-52-7) → ethyl N-benzylideneglycinate (40682-54-0)

Guidance literature:

ethyl 2-aminoacetate hydrochloride; With magnesium sulfate; triethylamine; In dichloromethane; at 20 ℃; for 1h;

benzaldehyde; In dichloromethane; at 20 ℃;

DOI:10.1021/jo500547y

upstream raw materials:

benzaldehyde

GlyOEt*HCl

glycine ethyl ester hydrochloride

benzyl bromide

Downstream raw materials:

2-(N-benzylacetamido)acetic acid

C₁₇H₂₁NO₃

3-Ethoxycarbonyl-2-{[1-phenyl-meth-(E)-ylidene]-amino}-pentanedioic acid diethyl ester

3-(4-Chloro-phenyl)-5-oxo-5-phenyl-2-{[1-phenyl-meth-(Z)-ylidene]-amino}-pentanoic acid methyl ester

Refernces

• 1、 Timofeeva, Daria S.,Ofial, Armin R.,Mayr, Herbert. "Nucleophilic reactivities of Schiff base derivatives of amino acids". supporting information. p. 459 - 463. Retrieved 2019/01/04.
• 2、 Luo, Zheng,Liu, Yan,Wang, Chao,Fang, Danjun,Zhou, Junyu,Hu, Huayou. "Application of the Cu(i)/TEMPO/O2 catalytic system for aerobic oxidative dehydrogenative aromatization of pyrrolidines". supporting information. p. 4609 - 4613. Retrieved 2019/09/09.