Regadenoson

Base Information Edit

Chemical Name:Regadenoson
CAS No.:313348-27-5
Molecular Formula:C₁₅H₁₈N₈O₅
Molecular Weight:390.359
Hs Code.:
European Community (EC) Number:690-885-5
UNII:7AXV542LZ4
DSSTox Substance ID:DTXSID4057712
Nikkaji Number:J1.806.399I
Wikipedia:Regadenoson
Wikidata:Q7307897
NCI Thesaurus Code:C171933
Pharos Ligand ID:ZWG9SA3JUZMW
Metabolomics Workbench ID:149683
ChEMBL ID:CHEMBL317052
Mol file:313348-27-5.mol

Synonyms:CVT 3146;CVT-3146;CVT3146;Lexiscan;regadenoson

Suppliers and Price of Regadenoson

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Regadenoson
5mg
$ 368.00

TRC
Regadenoson
50mg
$ 420.00

Medical Isotopes, Inc.
Regadenoson
25 mg
$ 2200.00

DC Chemicals
Regadenoson >98%
1 g
$ 1500.00

DC Chemicals
Regadenoson >98%
250 mg
$ 750.00

DC Chemicals
Regadenoson >98%
100 mg
$ 450.00

CSNpharm
Regadenoson
25mg
$ 288.00

ChemScene
Regadenoson 99.59%
50mg
$ 348.00

ChemScene
Regadenoson 99.59%
10mg
$ 168.00

ChemScene
Regadenoson 99.59%
25mg
$ 228.00

Total 71 raw suppliers

Chemical Property of Regadenoson Edit

Chemical Property:

Appearance/Colour:Off-white solid
Melting Point:158-160 °C
Refractive Index:1.896
PKA:13.07±0.70(Predicted)
PSA：186.46000
Density:1.98 g/cm³
LogP:-1.46260
Storage Temp.:-20°C Freezer, Under Inert Atmosphere
Solubility.:DMSO (Slightly), Methanol (Slightly, Sonicated)
XLogP3:-1.5
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:4
Exact Mass:390.14001570
Heavy Atom Count:28
Complexity:587

Purity/Quality:

99%MIN ^*data from raw suppliers

Regadenoson ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNC(=O)C1=CN(N=C1)C2=NC(=C3C(=N2)N(C=N3)C4C(C(C(O4)CO)O)O)N
Isomeric SMILES:CNC(=O)C1=CN(N=C1)C2=NC(=C3C(=N2)N(C=N3)[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O)N
Recent ClinicalTrials:A Study to Evaluate the Safety and Pharmacokinetics of Regadenoson in Pediatric Patients
Recent EU Clinical Trials:EVALUATION OF PATIENTS WITH TOTAL CORONARY OCCLUSIONS WITH MULTIMODALITY IMAGE
Recent NIPH Clinical Trials:An open-label, dose escalation, multicenter study to determine the effect on coronary blood flow and safety of NMB46 in subjects undergoing a clinically indicated cardiac catheterization.
Description Lexiscan ?(regadenoson) is an injectable adenosine A2A receptor agonist for use as a pharmacologic stress agent in myocardial perfusion imaging (MPI) studies in patients unable to undergo adequate exercise induced stress. Regadenoson is the first adenosine A2A receptor agonist shown to be safe and effective as a pharmacologic stress agent in MPI studies. It is delivered as a rapid bolus (approximately 10 seconds) with no dose adjustment required for body weight. The product was developed under a license and collaboration agreement between CV Therapeutics and Astellas, and was launched by Astellas in June of 2008.
Uses A selective A2A adenosine receptor agonist in myocardial imaging Regadenoson is a selective, short-acting adenosine A2A receptor agonist (Ki = 1.1 nM for pig striatum A2A receptor). It increases coronary blood flow 3.4- to 3.8-fold with a half-time to reversal of 1.9-2.6 minutes in open-chest anesthetized pigs. Regadenoson is used to induce hyperemia (increased blood flow), particularly in the context of myocardial perfusion imaging. It has also been found to increase the delivery of compounds to the central nervous system through the blood-brain barrier in animals. Regadenoson is a selective and potent A2A adenosine receptor agonist (1). The adenosine A2A receptor is a G-protein-coupled receptor and a key therapeutic target for oncologic, inflammatory, Parkinson''s and cardiovascular diseases (2). In rodent studies, it has been shown that co-administration of Regadenoson with Temozolomide (T017775) can increase Temozolomide concentration in the brain (3).

Technology Process of Regadenoson

There total 24 articles about Regadenoson which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%