Technology Process of 4-(t-butyloxycarbonylmethylthio)-phenyl boronic acid
There total 4 articles about 4-(t-butyloxycarbonylmethylthio)-phenyl boronic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 92 percent / sodium hydride in oil / tetrahydrofuran / 14 h / 20 °C
2.1: n-butyl lithium / tetrahydrofuran; hexane / 0.25 h / -78 °C
2.2: 77 percent / tri-isopropyl borate / tetrahydrofuran / 4 h / -78 - -20 °C
3.1: 88 percent / trifluoroacetic acid / CH2Cl2
4.1: 71 percent / potassium carbonate; sodium iodide / acetonitrile / 20 h
With
n-butyllithium; sodium hydride; potassium carbonate; trifluoroacetic acid; sodium iodide;
In
tetrahydrofuran; hexane; dichloromethane; acetonitrile;
1.1: Alkylation / 2.1: Metallation / 2.2: Acylation / 3.1: desilylation / 4.1: Alkylation;
DOI:10.1016/S0022-328X(99)00086-8
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyl lithium / tetrahydrofuran; hexane / 0.25 h / -78 °C
1.2: 77 percent / tri-isopropyl borate / tetrahydrofuran / 4 h / -78 - -20 °C
2.1: 88 percent / trifluoroacetic acid / CH2Cl2
3.1: 71 percent / potassium carbonate; sodium iodide / acetonitrile / 20 h
With
n-butyllithium; potassium carbonate; trifluoroacetic acid; sodium iodide;
In
tetrahydrofuran; hexane; dichloromethane; acetonitrile;
1.1: Metallation / 1.2: Acylation / 2.1: desilylation / 3.1: Alkylation;
DOI:10.1016/S0022-328X(99)00086-8
