2-benzo<1,3>dioxol-5-yl-4-(4-methoxyphenyl)-4-oxobutyric acid methyl ester

Base Information

• Chemical Name: 2-benzo<1,3>dioxol-5-yl-4-(4-methoxyphenyl)-4-oxobutyric acid methyl ester
• CAS No.: 162256-49-7
• Molecular Formula: C₁₉H₁₈O₆
• Molecular Weight: 342.348
• Mol file: 162256-49-7.mol

Synonyms:2-benzo<1,3>dioxol-5-yl-4-(4-methoxyphenyl)-4-oxobutyric acid methyl ester

Chemical Property of 2-benzo<1,3>dioxol-5-yl-4-(4-methoxyphenyl)-4-oxobutyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzo<1,3>dioxol-5-yl-4-(4-methoxyphenyl)-4-oxobutyric acid methyl ester

There total 7 articles about 2-benzo<1,3>dioxol-5-yl-4-(4-methoxyphenyl)-4-oxobutyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methanol (67-56-1) + 2-(1,3-benzodioxol-5-yl)-1-(4-methoxyphenyl)-4-oxobutyronitrile (162256-48-6) → 2-benzo<1,3>dioxol-5-yl-4-(4-methoxyphenyl)-4-oxobutyric acid methyl ester (162256-49-7)

Guidance literature:

With toluene-4-sulfonic acid; In 1,4-dioxane; for 12h; Heating;

Reference yield:

(E)-1-(4-methoxyphenyl)-3-(3,4-methylenedioxyphenyl)prop-2-en-1-one (144309-50-2) → 2-benzo<1,3>dioxol-5-yl-4-(4-methoxyphenyl)-4-oxobutyric acid methyl ester (162256-49-7)

Guidance literature:

Multi-step reaction with 2 steps

1: HOAc / 2-ethoxy-ethanol / 100 °C

2: p-TsOH / Heating

With toluene-4-sulfonic acid; acetic acid; In 2-ethoxy-ethanol;

DOI:10.1021/jm980504w

Reference yield:

piperonal (120-57-0,30024-74-9) → 2-benzo<1,3>dioxol-5-yl-4-(4-methoxyphenyl)-4-oxobutyric acid methyl ester (162256-49-7)

Guidance literature:

Multi-step reaction with 3 steps

1: NaOH / ethanol

2: HOAc / 2-ethoxy-ethanol / 100 °C

3: p-TsOH / Heating

With sodium hydroxide; toluene-4-sulfonic acid; acetic acid; In 2-ethoxy-ethanol; ethanol;

DOI:10.1021/jm980504w

upstream raw materials:

methanol

2-(1,3-benzodioxol-5-yl)-1-(4-methoxyphenyl)-4-oxobutyronitrile

piperonal

(E)-1-(4-methoxyphenyl)-3-(3,4-methylenedioxyphenyl)prop-2-en-1-one

Downstream raw materials:

3-Benzo[1,3]dioxol-5-yl-5-hydroxy-5-(4-methoxy-phenyl)-4-(3,4,5-trimethoxy-benzyl)-5H-furan-2-one