2-(4-(3-hydroxyphenyl)-6-morpholino-1,3,5-triazin-2-ylamino)-N,N-dimethylacetamide

Base Information

Chemical Name:2-(4-(3-hydroxyphenyl)-6-morpholino-1,3,5-triazin-2-ylamino)-N,N-dimethylacetamide
CAS No.:1391925-32-8
Molecular Formula:C₁₇H₂₂N₆O₃
Molecular Weight:358.4
Hs Code.:

Synonyms:2-(4-(3-hydroxyphenyl)-6-morpholino-1,3,5-triazin-2-ylamino)-N,N-dimethylacetamide

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Chemical Property of 2-(4-(3-hydroxyphenyl)-6-morpholino-1,3,5-triazin-2-ylamino)-N,N-dimethylacetamide

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Technology Process of 2-(4-(3-hydroxyphenyl)-6-morpholino-1,3,5-triazin-2-ylamino)-N,N-dimethylacetamide

There total 3 articles about 2-(4-(3-hydroxyphenyl)-6-morpholino-1,3,5-triazin-2-ylamino)-N,N-dimethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1391925-59-9
2-(4-(3-hydroxyphenyl)-6-morpholino-1,3,5-triazin-2-ylamino)acetic acid

: 124-40-3
dimethyl amine

: 1391925-32-8
2-(4-(3-hydroxyphenyl)-6-morpholino-1,3,5-triazin-2-ylamino)-N,N-dimethylacetamide

Guidance literature:: 2-(4-(3-hydroxyphenyl)-6-morpholino-1,3,5-triazin-2-ylamino)acetic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

dimethyl amine; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/acsmedchemlett.5b00322

Reference yield:

: 6601-22-5
2,6-Dichloro-4-morpholino-1,3,5-triazine

: 1391925-32-8
2-(4-(3-hydroxyphenyl)-6-morpholino-1,3,5-triazin-2-ylamino)-N,N-dimethylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / acetone; water / 15 h / 20 °C

2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 0.33 h / 120 °C / Inert atmosphere; Microwave irradiation

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.33 h / 20 °C

3.2: 18 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; acetone; 2.1: |Suzuki Coupling;
DOI:10.1021/acsmedchemlett.5b00322