(S)-2-(3-(benzyloxy)-4-((R)-1-(triethylsilyloxy)but-3-enyl)isoxazol-5-yl)-2-(tert-butyldimethylsilyloxy)ethanol

Base Information

Chemical Name:(S)-2-(3-(benzyloxy)-4-((R)-1-(triethylsilyloxy)but-3-enyl)isoxazol-5-yl)-2-(tert-butyldimethylsilyloxy)ethanol
CAS No.:1410805-26-3
Molecular Formula:C₂₈H₄₇NO₅Si₂
Molecular Weight:533.856
Hs Code.:

Synonyms:(S)-2-(3-(benzyloxy)-4-((R)-1-(triethylsilyloxy)but-3-enyl)isoxazol-5-yl)-2-(tert-butyldimethylsilyloxy)ethanol

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Chemical Property of (S)-2-(3-(benzyloxy)-4-((R)-1-(triethylsilyloxy)but-3-enyl)isoxazol-5-yl)-2-(tert-butyldimethylsilyloxy)ethanol

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Technology Process of (S)-2-(3-(benzyloxy)-4-((R)-1-(triethylsilyloxy)but-3-enyl)isoxazol-5-yl)-2-(tert-butyldimethylsilyloxy)ethanol

There total 7 articles about (S)-2-(3-(benzyloxy)-4-((R)-1-(triethylsilyloxy)but-3-enyl)isoxazol-5-yl)-2-(tert-butyldimethylsilyloxy)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1410805-25-2
3-(benzyloxy)-5-((S)-8,8-diethyl-2,2,3,3-tetramethyl-4,7-dioxa-3,8-disiladecan-5-yl)-4-((R)-1-(triethyl-silyloxy)but-3-enyl)isoxazole

: 1410805-26-3
(S)-2-(3-(benzyloxy)-4-((R)-1-(triethylsilyloxy)but-3-enyl)isoxazol-5-yl)-2-(tert-butyldimethylsilyloxy)ethanol

Guidance literature:: With acetic acid; In methanol; at 0 ℃; for 26h; Inert atmosphere;
DOI:10.1021/ol302691j

Reference yield:

: 1410805-21-8
C₂₆H₄₃NO₆Si₂

: 1410805-26-3
(S)-2-(3-(benzyloxy)-4-((R)-1-(triethylsilyloxy)but-3-enyl)isoxazol-5-yl)-2-(tert-butyldimethylsilyloxy)ethanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisobutylaluminium hydride / hexane; toluene / 2 h / -78 °C / Inert atmosphere

2.1: sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine / dichloromethane; dimethyl sulfoxide / 1 h / 0 °C / Inert atmosphere

3.1: pentane; diethyl ether / 0.75 h / -78 - 0 °C / Inert atmosphere

4.1: pyridine hydrogenfluoride; THF-pyridine / tetrahydrofuran / 0.75 h / 20 °C / Inert atmosphere

4.2: 1 h / 20 °C / Inert atmosphere

5.1: acetic acid / methanol / 26 h / 0 °C / Inert atmosphere

With THF-pyridine; sulfur trioxide pyridine complex; diisobutylaluminium hydride; pyridine hydrogenfluoride; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; dimethyl sulfoxide; toluene; pentane;
DOI:10.1021/ol302691j

Reference yield:

: 1410805-23-0
C₂₈H₄₇NO₅Si₂

: 1410805-26-3
(S)-2-(3-(benzyloxy)-4-((R)-1-(triethylsilyloxy)but-3-enyl)isoxazol-5-yl)-2-(tert-butyldimethylsilyloxy)ethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine hydrogenfluoride; THF-pyridine / tetrahydrofuran / 0.75 h / 20 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

2.1: acetic acid / methanol / 26 h / 0 °C / Inert atmosphere

With THF-pyridine; pyridine hydrogenfluoride; acetic acid; In tetrahydrofuran; methanol;
DOI:10.1021/ol302691j