Technology Process of 3-(benzyloxy)-5-((S)-8,8-diethyl-2,2,3,3-tetramethyl-4,7-dioxa-3,8-disiladecan-5-yl)-4-((R)-1-(triethyl-silyloxy)but-3-enyl)isoxazole
There total 7 articles about 3-(benzyloxy)-5-((S)-8,8-diethyl-2,2,3,3-tetramethyl-4,7-dioxa-3,8-disiladecan-5-yl)-4-((R)-1-(triethyl-silyloxy)but-3-enyl)isoxazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C28H47NO5Si2;
With
THF-pyridine; pyridine hydrogenfluoride;
In
tetrahydrofuran;
at 20 ℃;
for 0.75h;
Inert atmosphere;
tert-butyldimethylsilyl chloride;
With
1H-imidazole;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 1h;
Inert atmosphere;
DOI:10.1021/ol302691j
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: diisobutylaluminium hydride / hexane; toluene / 2 h / -78 °C / Inert atmosphere
2.1: sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine / dichloromethane; dimethyl sulfoxide / 1 h / 0 °C / Inert atmosphere
3.1: pentane; diethyl ether / 0.75 h / -78 - 0 °C / Inert atmosphere
4.1: pyridine hydrogenfluoride; THF-pyridine / tetrahydrofuran / 0.75 h / 20 °C / Inert atmosphere
4.2: 1 h / 20 °C / Inert atmosphere
With
THF-pyridine; sulfur trioxide pyridine complex; diisobutylaluminium hydride; pyridine hydrogenfluoride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; dimethyl sulfoxide; toluene; pentane;
DOI:10.1021/ol302691j
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: (R,R)-(-)-2,6-bis[2-(hydroxyldiphenylmethyl)-1-pyrrolidinyl-methyl]-4-methylphenole; dimethyl zinc(II) / toluene / 36 h / 20 °C / Inert atmosphere
2.1: 1H-imidazole / N,N-dimethyl-formamide / 4 h / 0 °C / Inert atmosphere
3.1: potassium hydrogencarbonate; N-chloro-succinimide / ethyl acetate / 84 h / 20 - 48 °C / Inert atmosphere
4.1: diisobutylaluminium hydride / hexane; toluene / 2 h / -78 °C / Inert atmosphere
5.1: sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine / dichloromethane; dimethyl sulfoxide / 1 h / 0 °C / Inert atmosphere
6.1: pentane; diethyl ether / 0.75 h / -78 - 0 °C / Inert atmosphere
7.1: pyridine hydrogenfluoride; THF-pyridine / tetrahydrofuran / 0.75 h / 20 °C / Inert atmosphere
7.2: 1 h / 20 °C / Inert atmosphere
With
1H-imidazole; N-chloro-succinimide; THF-pyridine; (R,R)-(-)-2,6-bis[2-(hydroxyldiphenylmethyl)-1-pyrrolidinyl-methyl]-4-methylphenole; dimethyl zinc(II); sulfur trioxide pyridine complex; diisobutylaluminium hydride; potassium hydrogencarbonate; pyridine hydrogenfluoride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene; pentane;
DOI:10.1021/ol302691j
