1-t-Butoxycarbonyl-4-(4-fluorobenzyloxymethyl)piperidine

Base Information

Chemical Name:1-t-Butoxycarbonyl-4-(4-fluorobenzyloxymethyl)piperidine
CAS No.:123855-52-7
Molecular Formula:C₁₈H₂₆FNO₃
Molecular Weight:323.408
Hs Code.:

Synonyms:1-t-Butoxycarbonyl-4-(4-fluorobenzyloxymethyl)piperidine;123855-52-7;SCHEMBL7871022;IIZRWCVJYCSMLK-UHFFFAOYSA-N;DB-337400

Suppliers and Price of 1-t-Butoxycarbonyl-4-(4-fluorobenzyloxymethyl)piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-t-Butoxycarbonyl-4-(4-fluorobenzyloxymethyl)piperidine

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:323.18967185
Heavy Atom Count:23
Complexity:367

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(CC1)COCC2=CC=C(C=C2)F

Technology Process of 1-t-Butoxycarbonyl-4-(4-fluorobenzyloxymethyl)piperidine

There total 3 articles about 1-t-Butoxycarbonyl-4-(4-fluorobenzyloxymethyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.9%

: 160296-41-3
4-[(4-fluorophenyl)hydroxymethyl]piperidine-1-carboxylic acid tert-butyl ester

: 74-88-4
methyl iodide

: 123855-52-7
tert-butyl 4-[(4-fluorophenyl)methoxymethyl]piperidine-1-carboxylate

Guidance literature:: 4-[(4-fluorophenyl)hydroxymethyl]piperidine-1-carboxylic acid tert-butyl ester; With sodium hydride; In tetrahydrofuran; mineral oil; for 0.5h; Cooling with ice;

methyl iodide; In tetrahydrofuran; mineral oil; for 0.5h;

Reference yield:

: 459-46-1
4-Fluorobenzyl bromide

: 123855-52-7
tert-butyl 4-[(4-fluorophenyl)methoxymethyl]piperidine-1-carboxylate

Guidance literature:: tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate; With sodium hydride; In 1-methyl-pyrrolidin-2-one; for 0.166667h;

4-Fluorobenzyl bromide; In 1-methyl-pyrrolidin-2-one; for 3h;