2-Amino-N-[3-(2-chloro-benzoyl)-5-(2-p-tolyl-ethyl)-thiophen-2-yl]-acetamide

Base Information

Chemical Name:2-Amino-N-[3-(2-chloro-benzoyl)-5-(2-p-tolyl-ethyl)-thiophen-2-yl]-acetamide
CAS No.:183130-07-6
Molecular Formula:C₂₂H₂₁ClN₂O₂S
Molecular Weight:412.94
Hs Code.:

Synonyms:2-Amino-N-[3-(2-chloro-benzoyl)-5-(2-p-tolyl-ethyl)-thiophen-2-yl]-acetamide

Suppliers and Price of 2-Amino-N-[3-(2-chloro-benzoyl)-5-(2-p-tolyl-ethyl)-thiophen-2-yl]-acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-Amino-N-[3-(2-chloro-benzoyl)-5-(2-p-tolyl-ethyl)-thiophen-2-yl]-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-Amino-N-[3-(2-chloro-benzoyl)-5-(2-p-tolyl-ethyl)-thiophen-2-yl]-acetamide

There total 8 articles about 2-Amino-N-[3-(2-chloro-benzoyl)-5-(2-p-tolyl-ethyl)-thiophen-2-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1027270-89-8
N-[3-(2-Chloro-benzoyl)-5-(2-p-tolyl-ethyl)-thiophen-2-yl]-2-iodo-acetamide

: 183130-07-6
2-Amino-N-[3-(2-chloro-benzoyl)-5-(2-p-tolyl-ethyl)-thiophen-2-yl]-acetamide

Guidance literature:: With ammonia; In tetrahydrofuran; at -30 - 20 ℃; for 4h;
DOI:10.1016/0223-5234(96)85877-6

Reference yield:

: 4619-20-9
3-(4-methylbenzoyl)propionic acid

: 183130-07-6
2-Amino-N-[3-(2-chloro-benzoyl)-5-(2-p-tolyl-ethyl)-thiophen-2-yl]-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: hydrazine hydrate, potassium hydroxide / ethane-1,2-diol / 20 - 160 °C

2: NaBH₄, BF₃*OEt₂

3: 2,2,6,6-tetramethyl-1-piperidinyloxy, 5percent aq. sodium bicarbonate, 10percent aq. sodium hypochlorite / toluene / 0.5 h / 0 - 5 °C

4: triethylamine, sulfur / dimethylformamide / 4 h / 50 - 60 °C

5: CHCl₃ / 2 h / Heating

6: sodium iodide / tetrahydrofuran / 2 h / Heating

7: liquid ammonia / tetrahydrofuran / 4 h / -30 - 20 °C

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; potassium hydroxide; sodium hypochlorite; sodium tetrahydroborate; boron trifluoride diethyl etherate; ammonia; sodium hydrogencarbonate; sulfur; hydrazine hydrate; triethylamine; sodium iodide; In tetrahydrofuran; chloroform; ethylene glycol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/0223-5234(96)85877-6

Reference yield:

: 53392-07-7
4-(4-methylphenyl)butan-1-ol

: 183130-07-6
2-Amino-N-[3-(2-chloro-benzoyl)-5-(2-p-tolyl-ethyl)-thiophen-2-yl]-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 2,2,6,6-tetramethyl-1-piperidinyloxy, 5percent aq. sodium bicarbonate, 10percent aq. sodium hypochlorite / toluene / 0.5 h / 0 - 5 °C

2: triethylamine, sulfur / dimethylformamide / 4 h / 50 - 60 °C

3: CHCl₃ / 2 h / Heating

4: sodium iodide / tetrahydrofuran / 2 h / Heating

5: liquid ammonia / tetrahydrofuran / 4 h / -30 - 20 °C

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; ammonia; sodium hydrogencarbonate; sulfur; triethylamine; sodium iodide; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1016/0223-5234(96)85877-6