N-[3-(2-Chloro-benzoyl)-5-(2-p-tolyl-ethyl)-thiophen-2-yl]-2-iodo-acetamide

Base Information

Chemical Name:N-[3-(2-Chloro-benzoyl)-5-(2-p-tolyl-ethyl)-thiophen-2-yl]-2-iodo-acetamide
CAS No.:1027270-89-8
Molecular Formula:C₂₂H₁₉ClINO₂S
Molecular Weight:523.822
Hs Code.:

Synonyms:N-[3-(2-Chloro-benzoyl)-5-(2-p-tolyl-ethyl)-thiophen-2-yl]-2-iodo-acetamide

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Chemical Property of N-[3-(2-Chloro-benzoyl)-5-(2-p-tolyl-ethyl)-thiophen-2-yl]-2-iodo-acetamide

Chemical Property:

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Technology Process of N-[3-(2-Chloro-benzoyl)-5-(2-p-tolyl-ethyl)-thiophen-2-yl]-2-iodo-acetamide

There total 7 articles about N-[3-(2-Chloro-benzoyl)-5-(2-p-tolyl-ethyl)-thiophen-2-yl]-2-iodo-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 183129-99-9
2-Chloro-N-[3-(2-chloro-benzoyl)-5-(2-p-tolyl-ethyl)-thiophen-2-yl]-acetamide

: 1027270-89-8
N-[3-(2-Chloro-benzoyl)-5-(2-p-tolyl-ethyl)-thiophen-2-yl]-2-iodo-acetamide

Guidance literature:: With sodium iodide; In tetrahydrofuran; for 2h; Heating;
DOI:10.1016/0223-5234(96)85877-6

Reference yield:

: 4619-20-9
3-(4-methylbenzoyl)propionic acid

: 1027270-89-8
N-[3-(2-Chloro-benzoyl)-5-(2-p-tolyl-ethyl)-thiophen-2-yl]-2-iodo-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: hydrazine hydrate, potassium hydroxide / ethane-1,2-diol / 20 - 160 °C

2: NaBH₄, BF₃*OEt₂

3: 2,2,6,6-tetramethyl-1-piperidinyloxy, 5percent aq. sodium bicarbonate, 10percent aq. sodium hypochlorite / toluene / 0.5 h / 0 - 5 °C

4: triethylamine, sulfur / dimethylformamide / 4 h / 50 - 60 °C

5: CHCl₃ / 2 h / Heating

6: sodium iodide / tetrahydrofuran / 2 h / Heating

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; potassium hydroxide; sodium hypochlorite; sodium tetrahydroborate; boron trifluoride diethyl etherate; sodium hydrogencarbonate; sulfur; hydrazine hydrate; triethylamine; sodium iodide; In tetrahydrofuran; chloroform; ethylene glycol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/0223-5234(96)85877-6

Reference yield:

: 53392-07-7
4-(4-methylphenyl)butan-1-ol

: 1027270-89-8
N-[3-(2-Chloro-benzoyl)-5-(2-p-tolyl-ethyl)-thiophen-2-yl]-2-iodo-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 2,2,6,6-tetramethyl-1-piperidinyloxy, 5percent aq. sodium bicarbonate, 10percent aq. sodium hypochlorite / toluene / 0.5 h / 0 - 5 °C

2: triethylamine, sulfur / dimethylformamide / 4 h / 50 - 60 °C

3: CHCl₃ / 2 h / Heating

4: sodium iodide / tetrahydrofuran / 2 h / Heating

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium hydrogencarbonate; sulfur; triethylamine; sodium iodide; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1016/0223-5234(96)85877-6