4-nitro-2-vinylbenzaldehyde

Base Information

• Chemical Name: 4-nitro-2-vinylbenzaldehyde
• CAS No.: 1313762-43-4
• Molecular Formula: C₉H₇NO₃
• Molecular Weight: 177.159
• Mol file: 1313762-43-4.mol

Synonyms:4-nitro-2-vinylbenzaldehyde

Chemical Property of 4-nitro-2-vinylbenzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-nitro-2-vinylbenzaldehyde

There total 4 articles about 4-nitro-2-vinylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-bromo-4-nitro-benzaldehyde (5274-71-5) + potassium vinyltrifluoroborate → 4-nitro-2-vinylbenzaldehyde (1313762-43-4)

Guidance literature:

With caesium carbonate; triphenylphosphine; palladium dichloride; In tetrahydrofuran; water; at 85 ℃; for 22h; sealed tube; Inert atmosphere;

DOI:10.1039/c1cc10683j

Reference yield: 62.0%

2-bromo-4-nitro-benzaldehyde (5274-71-5) + 2,4,6-trivinylcyclotriboroxane*pyridine complex → 4-nitro-2-vinylbenzaldehyde (1313762-43-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In methanol; water; toluene; at 100 ℃; for 6.5h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.1c00472

Reference yield:

2-bromo-4-nitrotoluene (7745-93-9) → 4-nitro-2-vinylbenzaldehyde (1313762-43-4)

Guidance literature:

Multi-step reaction with 3 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / benzene / 16 h / Reflux; Inert atmosphere

2: sulfuric acid / 3 h / 60 °C / Inert atmosphere

3: caesium carbonate; triphenylphosphine; palladium dichloride / tetrahydrofuran; water / 22 h / 85 °C / sealed tube; Inert atmosphere

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; caesium carbonate; triphenylphosphine; palladium dichloride; In tetrahydrofuran; water; benzene;

DOI:10.1039/c1cc10683j

upstream raw materials:

2-bromo-1-dibromomethyl-4-nitrobenzene

2-bromo-4-nitro-benzaldehyde

2-bromo-4-nitrotoluene

Downstream raw materials:

5-nitro-2,3-dihydroinden-1-one

5-(4-nitro-2-vinylphenyl)oxazole

Refernces

• 1、 -. "ARYL AMIDE KINASE INHIBITORS". . . Retrieved 2015/02/02.