5274-71-5

Basic information

• Product Name: 2-Bromo-4-nitrobenzaldehyde
• Synonyms: 2-Bromo-4-nitrobenzaldehyde;ethyl 6-amino-4-(4-bromothiophen-2-yl)-5-cyano-2-propyl-4H-pyran-3-carboxylate;Benzaldehyde, 2-broMo-4-nitro-
• CAS NO: 5274-71-5
• Molecular Formula: C₇H₄BrNO₃
• Molecular Weight: 230.02
• Mol File: 5274-71-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 81-82 °C
• Boiling Point: 553.5°Cat760mmHg
• Flash Point: 288.5°C
• Appearance: /
• Density: 1.5g/cm³
• Vapor Pressure: 2.72E-12mmHg at 25°C
• Refractive Index: 1.614
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-Bromo-4-nitrobenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-4-nitrobenzaldehyde(5274-71-5)
• EPA Substance Registry System: 2-Bromo-4-nitrobenzaldehyde(5274-71-5)

Safety Data

• Hazardous Substances Data: 5274-71-5(Hazardous Substances Data)

Usage

General Description

2-Bromo-4-nitrobenzaldehyde is a chemical compound with the molecular formula C7H4BrNO3. It is a pale yellow solid with a molecular weight of 216.02 g/mol. 2-Bromo-4-nitrobenzaldehyde is widely used as a building block in organic synthesis and is often used in the production of pharmaceuticals and agrochemicals. Its chemical structure consists of a benzene ring with a bromine atom at the 2-position and a nitro group at the 4-position, as well as an aldehyde group. 2-Bromo-4-nitrobenzaldehyde has several applications in the chemical industry, including as an intermediate in the synthesis of dyes, perfumes, and other organic compounds. It is important to handle this compound with care, as it is toxic and can cause irritation to the skin and respiratory system.

InChI:InChI=1/C16H17BrN2O3S/c1-3-5-11-14(16(20)21-4-2)13(10(7-18)15(19)22-11)12-6-9(17)8-23-12/h6,8,13H,3-5,19H2,1-2H3

Upstream product

• 16426-64-5 2-bromo-4-nitrobenzoic acid 
• 7745-93-9 2-bromo-4-nitrotoluene 
• 470715-98-1 acetic acid acetoxy-(2-bromo-4-nitro-phenyl)-methyl ester 
• 940-05-6 2-bromo-1-(bromomethyl)-4-nitrobenzene 

Downstream Products

• 267648-14-6 3-bromo-4-(oxazol-5-yl)aniline 
• 1008-95-3 4-(oxazol-5-yl)aniline 
• 678969-66-9 5-(4-nitro-2-vinylphenyl)oxazole 
• 1341231-16-0 2-(hex-1-ynyl)-4-nitrobenzaldehyde 
• 186390-79-4 6-Nitro-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 1313762-43-4 4-nitro-2-vinylbenzaldehyde 

Relevant articles and documents

Tandem Pd-catalyzed C-C coupling/recyclization of 2-(2-bromoaryl)cyclopropane-1,1-dicarboxylates with primary nitro alkanes

The first successful synthesis of 1H-2,3-benzoxazine 3-oxides has been described. The efficiency of the approach is provided by the C-C-coupling of 2-(2-bromoaryl)cyclopropane-1,1-dicarboxylates with primary nitroalkanes catalyzed by Pd(dba)2/JohnPhos system followed by in situ recyclization of the intermediates. Several representative transformations allowing selective modification of the nitronate as well as malonate functionalities in the resulting compounds are demonstrated.

General synthetic strategies towards N-alkyl sulfoximine building blocks for medicinal chemistry and the use of dimethylsulfoximine as a versatile precursor

The sulfoximine group has great potential as a substituent in drug discovery, as evidenced by two new clinical candidates, and can be viewed as an isosteric alternative to the commonly used sulfone. Our aim was to improve the accessibility of this group by synthesising a diverse range of S-alkyl and N-alkyl sulfoximine building blocks with procedures that are applicable on a practical scale (>10 g). In particular, synthesis of the less well exploited N-alkyl sulfoximines and the use of dimethylsulfoximine as a versatile, commercially available precursor is discussed.

Versatile synthesis of isoquinolines and isochromenes by Pd-catalyzed oxidative carbonylation of (2-alkynyl)benzylideneamine derivatives

Isoquinoline-4-carboxylic esters 3 and isochromene-4-carboxylic esters 4 have been conveniently prepared by direct PdI2-catalyzed oxidative heterocyclization/alkoxycarbonylation of readily available (2- alkynylbenzylidene)amine derivatives. In particular, (2-alkynylbenzylidene) (tert-butyl)amines 2 selectively afforded isoquinoline derivatives 3 by N-cyclization, whereas N-(2-alkynylbenzylidene)-N′-phenylhydrazines 5 led to the formation of isochromenes 4 through O-cyclization ensuing from water attack on the imino group of the substrate. Reactions were carried out in alcoholic solvents at 80-100 °C and under 20-80 atm (at 25 °C) of a 4:1 mixture of CO/air, in the presence of PdI2 (2-10 mol-%) in conjunction with KI (KI/PdI2 molar ratio = 10). In the case of imines 2, the use of a dehydration agent, such as trialkyl orthoformate, was necessary to obtain satisfactory yields of isoquinolines 3.