5'-O-dimethoxytrityl-1-N-(N',N'-diphenylcarbamoyl)-2-aza-2'-deoxyinosine-3'-O-2-cyanoethyl-N,N-diisopropylaminophosphoramidite

Base Information

Chemical Name:5'-O-dimethoxytrityl-1-N-(N',N'-diphenylcarbamoyl)-2-aza-2'-deoxyinosine-3'-O-2-cyanoethyl-N,N-diisopropylaminophosphoramidite
CAS No.:139123-78-7
Molecular Formula:C₅₂H₅₅N₈O₈P
Molecular Weight:951.031
Hs Code.:

Synonyms:5'-O-dimethoxytrityl-1-N-(N',N'-diphenylcarbamoyl)-2-aza-2'-deoxyinosine-3'-O-2-cyanoethyl-N,N-diisopropylaminophosphoramidite

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Chemical Property of 5'-O-dimethoxytrityl-1-N-(N',N'-diphenylcarbamoyl)-2-aza-2'-deoxyinosine-3'-O-2-cyanoethyl-N,N-diisopropylaminophosphoramidite

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Technology Process of 5'-O-dimethoxytrityl-1-N-(N',N'-diphenylcarbamoyl)-2-aza-2'-deoxyinosine-3'-O-2-cyanoethyl-N,N-diisopropylaminophosphoramidite

There total 8 articles about 5'-O-dimethoxytrityl-1-N-(N',N'-diphenylcarbamoyl)-2-aza-2'-deoxyinosine-3'-O-2-cyanoethyl-N,N-diisopropylaminophosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 139123-77-6
5'-O-dimethoxytrityl-1-N-(N',N'-diphenylcarbamoyl)-2-aza-2'-deoxyinosine

: 139123-78-7
5'-O-dimethoxytrityl-1-N-(N',N'-diphenylcarbamoyl)-2-aza-2'-deoxyinosine-3'-O-2-cyanoethyl-N,N-diisopropylaminophosphoramidite

Guidance literature:: With triethylamine; In dichloromethane; for 0.5h;
DOI:10.1016/S0040-4020(01)81004-8

Reference yield:

: 139123-76-5
1-N-(N',N'-diphenylcarbamoyl)-2-aza-2'-deoxyinosine

: 139123-78-7
5'-O-dimethoxytrityl-1-N-(N',N'-diphenylcarbamoyl)-2-aza-2'-deoxyinosine-3'-O-2-cyanoethyl-N,N-diisopropylaminophosphoramidite

Guidance literature:: Multi-step reaction with 2 steps

1: 50 percent / pyridine / 16 h

2: 70 percent / Et₃N / CH₂Cl₂ / 0.5 h

With pyridine; triethylamine; In dichloromethane;
DOI:10.1016/S0040-4020(01)81004-8

Reference yield:

: 139137-03-4
3',5'-O-tetraisopropyldisiloxane-1,3-diyl-2-azainosine

: 139123-78-7
5'-O-dimethoxytrityl-1-N-(N',N'-diphenylcarbamoyl)-2-aza-2'-deoxyinosine-3'-O-2-cyanoethyl-N,N-diisopropylaminophosphoramidite

Guidance literature:: Multi-step reaction with 6 steps

1: 63 percent / N,N-dimethylaminopyridine / acetonitrile / 3 h / Ambient temperature

2: 85 percent / pyridine, diisopropylethylamine / 1 h

3: Bu₃SnH, AIBN / toluene / 6 h / 75 °C

4: Bu₄NF / tetrahydrofuran / 0.25 h

5: 50 percent / pyridine / 16 h

6: 70 percent / Et₃N / CH₂Cl₂ / 0.5 h

With pyridine; dmap; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;
DOI:10.1016/S0040-4020(01)81004-8