5'-O-dimethoxytrityl-1-N-(N',N'-diphenylcarbamoyl)-2-aza-2'-deoxyinosine

Base Information

Chemical Name:5'-O-dimethoxytrityl-1-N-(N',N'-diphenylcarbamoyl)-2-aza-2'-deoxyinosine
CAS No.:139123-77-6
Molecular Formula:C₄₃H₃₈N₆O₇
Molecular Weight:750.811
Hs Code.:

Synonyms:5'-O-dimethoxytrityl-1-N-(N',N'-diphenylcarbamoyl)-2-aza-2'-deoxyinosine

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Chemical Property of 5'-O-dimethoxytrityl-1-N-(N',N'-diphenylcarbamoyl)-2-aza-2'-deoxyinosine

Chemical Property:

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Technology Process of 5'-O-dimethoxytrityl-1-N-(N',N'-diphenylcarbamoyl)-2-aza-2'-deoxyinosine

There total 6 articles about 5'-O-dimethoxytrityl-1-N-(N',N'-diphenylcarbamoyl)-2-aza-2'-deoxyinosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 139123-76-5
1-N-(N',N'-diphenylcarbamoyl)-2-aza-2'-deoxyinosine

: 139123-77-6
5'-O-dimethoxytrityl-1-N-(N',N'-diphenylcarbamoyl)-2-aza-2'-deoxyinosine

Guidance literature:: With pyridine; for 16h;
DOI:10.1016/S0040-4020(01)81004-8

Reference yield:

: 139137-03-4
3',5'-O-tetraisopropyldisiloxane-1,3-diyl-2-azainosine

: 139123-77-6
5'-O-dimethoxytrityl-1-N-(N',N'-diphenylcarbamoyl)-2-aza-2'-deoxyinosine

Guidance literature:: Multi-step reaction with 5 steps

1: 63 percent / N,N-dimethylaminopyridine / acetonitrile / 3 h / Ambient temperature

2: 85 percent / pyridine, diisopropylethylamine / 1 h

3: Bu₃SnH, AIBN / toluene / 6 h / 75 °C

4: Bu₄NF / tetrahydrofuran / 0.25 h

5: 50 percent / pyridine / 16 h

With pyridine; dmap; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; toluene; acetonitrile;
DOI:10.1016/S0040-4020(01)81004-8

Reference yield:

: 139123-74-3
3',5'-O-tetraisopropyldisiloxane-1,3-diyl-2'-O-(phenoxythiocarbonyl)-2-azainosine

: 139123-77-6
5'-O-dimethoxytrityl-1-N-(N',N'-diphenylcarbamoyl)-2-aza-2'-deoxyinosine

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / pyridine, diisopropylethylamine / 1 h

2: Bu₃SnH, AIBN / toluene / 6 h / 75 °C

3: Bu₄NF / tetrahydrofuran / 0.25 h

4: 50 percent / pyridine / 16 h

With pyridine; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; toluene;
DOI:10.1016/S0040-4020(01)81004-8