2,4-Dinitro-benzoic acid (3R,4R,6R)-6-(6-dibenzoylamino-purin-9-yl)-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-pyran-3-yl ester

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Chemical Name:2,4-Dinitro-benzoic acid (3R,4R,6R)-6-(6-dibenzoylamino-purin-9-yl)-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-pyran-3-yl ester
CAS No.:173256-71-8
Molecular Formula:C₅₂H₄₁N₇O₁₁
Molecular Weight:939.938
Hs Code.:

Synonyms:2,4-Dinitro-benzoic acid (3R,4R,6R)-6-(6-dibenzoylamino-purin-9-yl)-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-pyran-3-yl ester

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Chemical Property of 2,4-Dinitro-benzoic acid (3R,4R,6R)-6-(6-dibenzoylamino-purin-9-yl)-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-pyran-3-yl ester

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Technology Process of 2,4-Dinitro-benzoic acid (3R,4R,6R)-6-(6-dibenzoylamino-purin-9-yl)-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-pyran-3-yl ester

There total 8 articles about 2,4-Dinitro-benzoic acid (3R,4R,6R)-6-(6-dibenzoylamino-purin-9-yl)-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-pyran-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 98-88-4
benzoyl chloride

: 173256-64-9
4'-O-(2,4-dinitrobenzoyl)-2',3'-dideoxy-3'-C-(methoxytrityl)oxyphenyl-α-L-threo-pentoyranosyl adenine

: 173256-71-8
2,4-Dinitro-benzoic acid (3R,4R,6R)-6-(6-dibenzoylamino-purin-9-yl)-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-pyran-3-yl ester

Guidance literature:: With pyridine; for 2h; Ambient temperature;
DOI:10.1016/0040-4020(95)00777-6

Reference yield:

: 162934-32-9
(2',3'-Dideoxy-β-D-glycero-pent-2'-enopyranosyl)-N⁶-benzoyladenine

: 173256-71-8
2,4-Dinitro-benzoic acid (3R,4R,6R)-6-(6-dibenzoylamino-purin-9-yl)-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: imidazole / dimethylformamide / 1 h / Ambient temperature

2: tributyltin hydride, AIBN / toluene / 4 h / Heating

3: KF, 35 percent H₂O₂, KHCO₃ / dimethylformamide

4: 57 percent / pyridine, DMAP

5: 46 percent / triphenylphosphine, diethyl azodicarboxylate / dioxane / 4 h

6: 73 percent / pyridine / 2 h / Ambient temperature

With pyridine; 1H-imidazole; dmap; potassium fluoride; 2,2'-azobis(isobutyronitrile); dihydrogen peroxide; tri-n-butyl-tin hydride; potassium hydrogencarbonate; triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/0040-4020(95)00777-6

Reference yield:

: 169514-16-3
N-{9-[(2R,5S)-5-(Bromomethyl-dimethyl-silanyloxy)-5,6-dihydro-2H-pyran-2-yl]-9H-purin-6-yl}-benzamide

: 173256-71-8
2,4-Dinitro-benzoic acid (3R,4R,6R)-6-(6-dibenzoylamino-purin-9-yl)-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: tributyltin hydride, AIBN / toluene / 4 h / Heating

2: KF, 35 percent H₂O₂, KHCO₃ / dimethylformamide

3: 57 percent / pyridine, DMAP

4: 46 percent / triphenylphosphine, diethyl azodicarboxylate / dioxane / 4 h

5: 73 percent / pyridine / 2 h / Ambient temperature

With pyridine; dmap; potassium fluoride; 2,2'-azobis(isobutyronitrile); dihydrogen peroxide; tri-n-butyl-tin hydride; potassium hydrogencarbonate; triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/0040-4020(95)00777-6