N-(5-(4-(hydroxymethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide

Base Information

Chemical Name:N-(5-(4-(hydroxymethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide
CAS No.:1142936-49-9
Molecular Formula:C₁₇H₁₆N₄O₂
Molecular Weight:308.34
Hs Code.:
Mol file:1142936-49-9.mol

Synonyms:cyclopropanecarboxylic acid [5-(4-hydroxymethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-amide

Suppliers and Price of N-(5-(4-(hydroxymethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 9 raw suppliers

Chemical Property of N-(5-(4-(hydroxymethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide

Chemical Property:

PKA:8.02±0.20(Predicted)
Density:1.45±0.1 g/cm3(Predicted)

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(5-(4-(hydroxymethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide

There total 5 articles about N-(5-(4-(hydroxymethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1142943-96-1
cyclopropanecarboxylic acid (5-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-amide

: 59016-93-2
p-hydroxymethylphenylboronic acid

: 1142936-49-9
cyclopropanecarboxylic acid [5-(4-hydroxymethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-amide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 90 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1010120-55-4
5-Bromo-[1,2,4]Triazolo[1,5-a]pyridine-2-ylamine

: 1142936-49-9
cyclopropanecarboxylic acid [5-(4-hydroxymethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / acetonitrile

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane; water / 90 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; triethylamine; In 1,4-dioxane; water; acetonitrile; 2: |Suzuki Coupling;
DOI:10.1358/dof.2014.039.08.2185917

Reference yield:

: 19798-81-3,1184170-10-2
2-Amino-6-bromopyridine

: 1142936-49-9
cyclopropanecarboxylic acid [5-(4-hydroxymethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane

2: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / ethanol; methanol

3: triethylamine / acetonitrile

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane; water / 90 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; hydroxylamine hydrochloride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetonitrile; 4: |Suzuki Coupling;
DOI:10.1358/dof.2014.039.08.2185917