tert‐butyl 7,8‐bis(acetyloxy)‐2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazine‐5‐carboxylate

Base Information

Chemical Name:tert‐butyl 7,8‐bis(acetyloxy)‐2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazine‐5‐carboxylate
CAS No.:1356332-99-4
Molecular Formula:C₃₀H₃₃N₃O₆
Molecular Weight:531.609
Hs Code.:

Synonyms:tert‐butyl 7,8‐bis(acetyloxy)‐2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazine‐5‐carboxylate

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Chemical Property of tert‐butyl 7,8‐bis(acetyloxy)‐2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazine‐5‐carboxylate

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Technology Process of tert‐butyl 7,8‐bis(acetyloxy)‐2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazine‐5‐carboxylate

There total 5 articles about tert‐butyl 7,8‐bis(acetyloxy)‐2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazine‐5‐carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356332-98-3
7,8-dihydroxy-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-carboxylic acid tert-butyl ester

: 108-24-7
acetic anhydride

: 1356332-99-4
tert‐butyl 7,8‐bis(acetyloxy)‐2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazine‐5‐carboxylate

Guidance literature:: With pyridine; at 20 ℃; for 18h;

Reference yield:

: 1356332-96-1
2,3-di-p-tolyl-5,6-dihydropyrido[2,3-b]pyrazine

: 1356332-99-4
tert‐butyl 7,8‐bis(acetyloxy)‐2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazine‐5‐carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / diethyl ether; hexanes / 0.17 h / -78 °C

1.2: -78 - 20 °C

2.1: sodium hydrogensulfite; potassium permanganate; methyl tributylammonium chloride / dichloromethane; water / 0 - 10 °C / Inert atmosphere

3.1: pyridine / 18 h / 20 °C

With pyridine; potassium permanganate; n-butyllithium; sodium hydrogensulfite; methyl tributylammonium chloride; In hexanes; diethyl ether; dichloromethane; water;

Reference yield:

: 1356332-97-2
2,3-di-p-tolylpyrido[2,3-b]pyrazine-5(6H)-carboxylic acid tert-butyl ester

: 1356332-99-4
tert‐butyl 7,8‐bis(acetyloxy)‐2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazine‐5‐carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogensulfite; potassium permanganate; methyl tributylammonium chloride / dichloromethane; water / 0 - 10 °C / Inert atmosphere

2: pyridine / 18 h / 20 °C

With pyridine; potassium permanganate; sodium hydrogensulfite; methyl tributylammonium chloride; In dichloromethane; water;