(E)-(3R,4S)-7-(tert-Butyl-diphenyl-silanyloxy)-5-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-1-phenylsulfanyl-hept-5-ene-3,4-diol

Base Information

Chemical Name:(E)-(3R,4S)-7-(tert-Butyl-diphenyl-silanyloxy)-5-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-1-phenylsulfanyl-hept-5-ene-3,4-diol
CAS No.:218435-07-5
Molecular Formula:C₄₁H₅₂O₅SSi
Molecular Weight:685.012
Hs Code.:

Synonyms:(E)-(3R,4S)-7-(tert-Butyl-diphenyl-silanyloxy)-5-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-1-phenylsulfanyl-hept-5-ene-3,4-diol

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Chemical Property of (E)-(3R,4S)-7-(tert-Butyl-diphenyl-silanyloxy)-5-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-1-phenylsulfanyl-hept-5-ene-3,4-diol

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Technology Process of (E)-(3R,4S)-7-(tert-Butyl-diphenyl-silanyloxy)-5-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-1-phenylsulfanyl-hept-5-ene-3,4-diol

There total 6 articles about (E)-(3R,4S)-7-(tert-Butyl-diphenyl-silanyloxy)-5-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-1-phenylsulfanyl-hept-5-ene-3,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 218435-03-1
(E)-(4S,5R)-3-[2-(4-Methoxy-benzyloxy)-ethyl]-6,6-dimethyl-7-phenylsulfanyl-hept-2-ene-1,4,5-triol

: 218435-07-5
(E)-(3R,4S)-7-(tert-Butyl-diphenyl-silanyloxy)-5-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-1-phenylsulfanyl-hept-5-ene-3,4-diol

Guidance literature:: With dmap; triethylamine; for 16h; Ambient temperature;
DOI:10.1016/S0040-4020(98)00889-8

Reference yield:

: 133094-78-7
3-(tert-butyldimethylsilanyloxy)-4,4-dimethyldihydro-2(3H)-furan-2-one

: 218435-07-5
(E)-(3R,4S)-7-(tert-Butyl-diphenyl-silanyloxy)-5-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-1-phenylsulfanyl-hept-5-ene-3,4-diol

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / Me₃Al / hexane; benzene / 1 h / Ambient temperature

2: CBr₄, PPh₃ / acetonitrile / 2 h / Ambient temperature

3: DBU / benzene / 48 h / Heating

4: 65 percent / di-isobutylaluminium hydride / hexane; CH₂Cl₂ / 2 h / -78 °C

5: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C, 45 min

6: 97 percent / TBAF / tetrahydrofuran / 3 h / Ambient temperature

7: 89 percent / DMAP, Et₃N / 16 h / Ambient temperature

With dmap; n-butyllithium; diisobutylaluminum hydride; carbon tetrabromide; tetrabutyl ammonium fluoride; trimethylaluminum; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; acetonitrile; benzene;
DOI:10.1016/S0040-4020(98)00889-8

Reference yield:

: 159351-19-6
(R)-2-(tert-Butyl-dimethyl-silanyloxy)-3,3-dimethyl-4-phenylsulfanyl-butyraldehyde

: 218435-07-5
(E)-(3R,4S)-7-(tert-Butyl-diphenyl-silanyloxy)-5-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-1-phenylsulfanyl-hept-5-ene-3,4-diol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -78 deg C, 45 min

2: 97 percent / TBAF / tetrahydrofuran / 3 h / Ambient temperature

3: 89 percent / DMAP, Et₃N / 16 h / Ambient temperature

With dmap; n-butyllithium; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran;
DOI:10.1016/S0040-4020(98)00889-8