C₂₉H₂₆O₃

Base Information

• Chemical Name: C₂₉H₂₆O₃
• CAS No.: 1259381-71-9
• Molecular Formula: C₂₉H₂₆O₃
• Molecular Weight: 422.524
• Mol file: 1259381-71-9.mol

Synonyms:C₂₉H₂₆O₃

Chemical Property of C₂₉H₂₆O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₉H₂₆O₃

There total 4 articles about C₂₉H₂₆O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-ethynyl-2-[2-(4-methoxyphenyl)ethynyl]benzene + 5-methoxy-2,2-dimethyl-2,3-dihydro-1H-inden-1-one (124688-06-8) → C29H26O3 (1259381-71-9)

Guidance literature:

1-ethynyl-2-[2-(4-methoxyphenyl)ethynyl]benzene; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

5-methoxy-2,2-dimethyl-2,3-dihydro-1H-inden-1-one; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ol102793a

Reference yield:

1-[2-(4-methoxyphenyl)ethynyl]-2-[2-(trimethylsilyl)ethynyl]benzene → C29H26O3 (1259381-71-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / methanol / 3 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 - 20 °C / Inert atmosphere

With potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane;

DOI:10.1021/ol102793a

Reference yield:

2-bromo-1-(trimethylsilylethynyl)benzene (38274-16-7) → C29H26O3 (1259381-71-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 12 h / 75 °C / Inert atmosphere

2.1: potassium carbonate / methanol / 3 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

3.2: 1 h / -78 - 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane;

DOI:10.1021/ol102793a

upstream raw materials:

5-methoxy-2,2-dimethyl-2,3-dihydro-1H-inden-1-one

2-bromo-1-(trimethylsilylethynyl)benzene

4-methoxyphenylacetylen

Downstream raw materials:

C₂₉H₂₆O₃