7-benzyloxy-1-(5'-benzyloxy-2'-bromo-4'-methoxybenzyl)-6-methoxy-3,4-dihydroisoquinoline

Base Information

Chemical Name:7-benzyloxy-1-(5'-benzyloxy-2'-bromo-4'-methoxybenzyl)-6-methoxy-3,4-dihydroisoquinoline
CAS No.:227088-17-7
Molecular Formula:C₃₂H₃₀BrNO₄
Molecular Weight:572.499
Hs Code.:

Synonyms:7-benzyloxy-1-(5'-benzyloxy-2'-bromo-4'-methoxybenzyl)-6-methoxy-3,4-dihydroisoquinoline

Suppliers and Price of 7-benzyloxy-1-(5'-benzyloxy-2'-bromo-4'-methoxybenzyl)-6-methoxy-3,4-dihydroisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 7-benzyloxy-1-(5'-benzyloxy-2'-bromo-4'-methoxybenzyl)-6-methoxy-3,4-dihydroisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 7-benzyloxy-1-(5'-benzyloxy-2'-bromo-4'-methoxybenzyl)-6-methoxy-3,4-dihydroisoquinoline

There total 8 articles about 7-benzyloxy-1-(5'-benzyloxy-2'-bromo-4'-methoxybenzyl)-6-methoxy-3,4-dihydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.1%

: 13232-98-9
N-(4'-benzyloxy-2-bromo-4-methoxyphenyl)-N-(4'-benzyloxy-3'-methoxyphenylethyl)acetamide

: 227088-17-7
7-benzyloxy-1-(5'-benzyloxy-2'-bromo-4'-methoxybenzyl)-6-methoxy-3,4-dihydroisoquinoline

Guidance literature:: With trichlorophosphate; In benzene; for 3h; Reflux;
DOI:10.3390/molecules13122935

Reference yield:

: 93-17-4
3,4-dimethoxyphenylacetonitrile

: 227088-17-7
7-benzyloxy-1-(5'-benzyloxy-2'-bromo-4'-methoxybenzyl)-6-methoxy-3,4-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: AlCl₃ / toluene

1.2: Br₂; AcOH / CH₂Cl₂ / -78 °C

2.1: 75 percent / NH₃; H₂ / Ra-Ni catalyst / ethanol / 70 °C / 7600 Torr

3.1: 61 percent / 3 h / 180 °C

4.1: 80 percent / K₂CO₃ / ethanol / 6 h / Heating

5.1: 76 percent / POCl₃ / acetonitrile / 4 h / Heating

With aluminium trichloride; ammonia; hydrogen; potassium carbonate; trichlorophosphate; Ra-Ni catalyst; In ethanol; toluene; acetonitrile; 5.1: Bischler-Napieralski ring-closure reaction;
DOI:10.1055/s-2006-926410

Reference yield:

: 4468-59-1
4-hydroxy-3-methoxyphenylacetonitrile

: 227088-17-7
7-benzyloxy-1-(5'-benzyloxy-2'-bromo-4'-methoxybenzyl)-6-methoxy-3,4-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / NH₃; H₂ / Ra-Ni catalyst / ethanol / 70 °C / 7600 Torr

2: 61 percent / 3 h / 180 °C

3: 80 percent / K₂CO₃ / ethanol / 6 h / Heating

4: 76 percent / POCl₃ / acetonitrile / 4 h / Heating

With ammonia; hydrogen; potassium carbonate; trichlorophosphate; Ra-Ni catalyst; In ethanol; acetonitrile; 4: Bischler-Napieralski ring-closure reaction;
DOI:10.1055/s-2006-926410