(1R,2S)-2-[4-(2-chloroethoxy)phenyl]-1,2-diphenyl-1-(hydroxymethyl)-cyclopropane

Base Information

Chemical Name:(1R,2S)-2-[4-(2-chloroethoxy)phenyl]-1,2-diphenyl-1-(hydroxymethyl)-cyclopropane
CAS No.:264620-36-2
Molecular Formula:C₂₄H₂₃ClO₂
Molecular Weight:378.898
Hs Code.:

Synonyms:(1R,2S)-2-[4-(2-chloroethoxy)phenyl]-1,2-diphenyl-1-(hydroxymethyl)-cyclopropane

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Chemical Property of (1R,2S)-2-[4-(2-chloroethoxy)phenyl]-1,2-diphenyl-1-(hydroxymethyl)-cyclopropane

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Technology Process of (1R,2S)-2-[4-(2-chloroethoxy)phenyl]-1,2-diphenyl-1-(hydroxymethyl)-cyclopropane

There total 5 articles about (1R,2S)-2-[4-(2-chloroethoxy)phenyl]-1,2-diphenyl-1-(hydroxymethyl)-cyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 264620-33-9
methyl (1R,2S)-2-[4-(2-chloroethoxy)phenyl]-1,2-diphenylcyclopropane-1-carboxylate

: 264620-36-2
(1R,2S)-2-[4-(2-chloroethoxy)phenyl]-1,2-diphenyl-1-(hydroxymethyl)-cyclopropane

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at -78 - 0 ℃; for 1.33333h;
DOI:10.1021/ol005563u

Reference yield:

: 3439-73-4
4-(2-chloroethoxy)benzophenone

: 264620-36-2
(1R,2S)-2-[4-(2-chloroethoxy)phenyl]-1,2-diphenyl-1-(hydroxymethyl)-cyclopropane

Guidance literature:: Multi-step reaction with 3 steps

1.1: BuLi / tetrahydrofuran; hexane / 1 h / 0 °C

1.2: 98 percent / tetrahydrofuran; hexane / 1 h / 23 °C

2.1: Rh₂(R-DOSP)4 / pentane / 23 °C

3.1: 94 percent / LiAlH₄ / tetrahydrofuran / 1.33 h / -78 - 0 °C

With lithium aluminium tetrahydride; n-butyllithium; Rh₂(R-DOSP)4; In tetrahydrofuran; hexane; pentane; 1.1: Elimination / 1.2: Substitution / 2.1: cyclopropanation / 3.1: Reduction;
DOI:10.1021/ol005563u

Reference yield:

: 22979-35-7
Methyl phenyldiazoacetate

: 264620-36-2
(1R,2S)-2-[4-(2-chloroethoxy)phenyl]-1,2-diphenyl-1-(hydroxymethyl)-cyclopropane

Guidance literature:: Multi-step reaction with 2 steps

1: Rh₂(R-DOSP)4 / pentane / 23 °C

2: 94 percent / LiAlH₄ / tetrahydrofuran / 1.33 h / -78 - 0 °C

With lithium aluminium tetrahydride; Rh₂(R-DOSP)4; In tetrahydrofuran; pentane; 1: cyclopropanation / 2: Reduction;
DOI:10.1021/ol005563u