4-(2-Chloroethoxy)benzophenone

Base Information

• Chemical Name: 4-(2-Chloroethoxy)benzophenone
• CAS No.: 3439-73-4
• Molecular Formula: C15H13ClO2
• Molecular Weight: 260.72
• Hs Code.: 2914700090
• European Community (EC) Number: 690-635-5
• DSSTox Substance ID: DTXSID40474589
• Nikkaji Number: J2.344.265E
• Wikidata: Q82304692
• Mol file: 3439-73-4.mol

Synonyms:4-(2-Chloroethoxy)benzophenone;3439-73-4;[4-(2-Chloroethoxy)phenyl]-phenylmethanone;Methanone, [4-(2-chloroethoxy)phenyl]phenyl-;EC 690-635-5;SCHEMBL10795926;4-(2-chloroethoxy) benzophenone;DTXSID40474589;AKOS009293578;NS00006676;A1-05773

Chemical Property of 4-(2-Chloroethoxy)benzophenone

Chemical Property:

• PSA: 26.30000
• LogP: 3.53520
• Storage Temp.: Refrigerator
• Solubility.: Acetone, Dichloromethane, Ethyl Acetate
• XLogP3: 4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 260.0604073
• Heavy Atom Count: 18
• Complexity: 253

Purity/Quality:

99.9% ^*data from raw suppliers

4-(2-Chloroethoxy)benzophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)OCCCl
• Uses: 4-(2-Chloroethoxy)benzophenone is a benzophenone derivative, used in the preparation of Tamoxifen and derivatives.

Technology Process of 4-(2-Chloroethoxy)benzophenone

There total 5 articles about 4-(2-Chloroethoxy)benzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1,2-dichloro-ethane (107-06-2,52399-93-6) + 4-Hydroxybenzophenone (1137-42-4) → 4-(2-chloroethoxy)benzophenone (3439-73-4)

Guidance literature:

With sodium hydroxide; benzyl tri-n-butylammonium bromide; In water; for 18h; Heating;

Reference yield: 87.0%

benzoyl chloride (98-88-4) + 2-chloroethoxybenzene (622-86-6) → 4-(2-chloroethoxy)benzophenone (3439-73-4)

Guidance literature:

With indium; In 1,4-dioxane; at 100 ℃; for 1h;

DOI:10.1016/j.tetlet.2006.06.099

Reference yield: 74.0%

4-Hydroxybenzophenone (1137-42-4) + 2-chloro-ethanol (107-07-3) → 4-(2-chloroethoxy)benzophenone (3439-73-4)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 23 ℃; for 19h;

DOI:10.1021/ol005563u

upstream raw materials:

1,2-dichloro-ethane

4-Hydroxybenzophenone

benzoyl chloride

2-chloroethoxybenzene

Downstream raw materials:

(Z)-1-<4-(2-chloroethoxy)phenyl>-1,2-diphenyl-1-butene

C₂₉H₃₄N₂O₂

(Z)-2-[4-(2-fluoroethoxy)phenyl]-1-[4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-1-phenylbut-1-ene

(Z)-1-[4-(2-chloroethoxy)phenyl]-2-(4-iodophenyl)-1-phenylbut-1-ene