(S)-3-(4-benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propionic acid cyclopentyl ester

Base Information

Chemical Name:(S)-3-(4-benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propionic acid cyclopentyl ester
CAS No.:914452-22-5
Molecular Formula:C₂₆H₃₃NO₅
Molecular Weight:439.552
Hs Code.:

Synonyms:(S)-3-(4-benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propionic acid cyclopentyl ester

Suppliers and Price of (S)-3-(4-benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propionic acid cyclopentyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-(4-benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propionic acid cyclopentyl ester

Chemical Property:

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Technology Process of (S)-3-(4-benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propionic acid cyclopentyl ester

There total 1 articles about (S)-3-(4-benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propionic acid cyclopentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.4%

: 96-41-3
Cyclopentanol

: 2130-96-3,54784-43-9
O-benzyl-N-tert-butoxycarbonyl-L-tyrosine

: 914452-22-5
(S)-3-(4-benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propionic acid cyclopentyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 22h;

Reference yield: 88.0%

: 914452-22-5
(S)-3-(4-benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propionic acid cyclopentyl ester

: 914452-23-6
(S)-2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionic acid cyclopentyl ester

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate; for 30h;

Reference yield:

: 914452-22-5
(S)-3-(4-benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propionic acid cyclopentyl ester

: 2-(S)-amino-3-[4-(4-{[(2-hydroxycarbamoyl-benzo[b]thiophen-6-ylmethyl)-amino]-methyl}-phenoxy)-cyclohexyl]-propionic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 30 h

2.1: hydrogen / platinum(IV) oxide / acetic acid; isopropyl alcohol / 16 h / 3750.38 Torr / sealed

3.1: triphenylphosphine / tetrahydrofuran / 0.17 h / 20 °C

3.2: 1.5 h / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate

5.1: 1,2-dichloro-ethane / 0.5 h

5.2: 1 h / 20 °C

6.1: hydrogenchloride / 1,4-dioxane / 1 h

7.1: lithium hydroxide; water / tetrahydrofuran / 8 h / 50 °C

7.2: 1 h

With hydrogenchloride; lithium hydroxide; water; hydrogen; triphenylphosphine; platinum(IV) oxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; acetic acid; ethyl acetate; 1,2-dichloro-ethane; isopropyl alcohol;