3-{4-[4-(benzyloxycarbonylamino-methyl)-phenoxy]-cyclohexyl}-2-(S)-tert-butoxycarbonylamino-propionic acid cyclopentyl ester

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Chemical Name:3-{4-[4-(benzyloxycarbonylamino-methyl)-phenoxy]-cyclohexyl}-2-(S)-tert-butoxycarbonylamino-propionic acid cyclopentyl ester
CAS No.:914645-83-3
Molecular Formula:C₃₄H₄₆N₂O₇
Molecular Weight:594.748
Hs Code.:

Synonyms:3-{4-[4-(benzyloxycarbonylamino-methyl)-phenoxy]-cyclohexyl}-2-(S)-tert-butoxycarbonylamino-propionic acid cyclopentyl ester

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Chemical Property of 3-{4-[4-(benzyloxycarbonylamino-methyl)-phenoxy]-cyclohexyl}-2-(S)-tert-butoxycarbonylamino-propionic acid cyclopentyl ester

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Technology Process of 3-{4-[4-(benzyloxycarbonylamino-methyl)-phenoxy]-cyclohexyl}-2-(S)-tert-butoxycarbonylamino-propionic acid cyclopentyl ester

There total 7 articles about 3-{4-[4-(benzyloxycarbonylamino-methyl)-phenoxy]-cyclohexyl}-2-(S)-tert-butoxycarbonylamino-propionic acid cyclopentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 914645-82-2
2(S)-tert-butoxycarbonylamino-3-(4-hydroxy-cyclohexyl)-propionic acid cyclopentyl ester

: 75383-60-7
(4-hydroxy-benzyl)carbamic acid benzyl ester

: 914645-83-3
3-{4-[4-(benzyloxycarbonylamino-methyl)-phenoxy]-cyclohexyl}-2-(S)-tert-butoxycarbonylamino-propionic acid cyclopentyl ester

Guidance literature:: 2(S)-tert-butoxycarbonylamino-3-(4-hydroxy-cyclohexyl)-propionic acid cyclopentyl ester; (4-hydroxy-benzyl)carbamic acid benzyl ester; With triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 0.166667h;

With di-isopropyl azodicarboxylate; In tetrahydrofuran; at 20 ℃; for 1.5h;

Reference yield:

: 96-41-3
Cyclopentanol

: 914645-83-3
3-{4-[4-(benzyloxycarbonylamino-methyl)-phenoxy]-cyclohexyl}-2-(S)-tert-butoxycarbonylamino-propionic acid cyclopentyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 22 h / 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 30 h

3.1: hydrogen / platinum(IV) oxide / acetic acid; isopropyl alcohol / 16 h / 3750.38 Torr / sealed

4.1: triphenylphosphine / tetrahydrofuran / 0.17 h / 20 °C

4.2: 1.5 h / 20 °C

With dmap; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; platinum(IV) oxide; palladium 10% on activated carbon; In tetrahydrofuran; acetic acid; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 2130-96-3,54784-43-9
O-benzyl-N-tert-butoxycarbonyl-L-tyrosine

: 914645-83-3
3-{4-[4-(benzyloxycarbonylamino-methyl)-phenoxy]-cyclohexyl}-2-(S)-tert-butoxycarbonylamino-propionic acid cyclopentyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 22 h / 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 30 h

3.1: hydrogen / platinum(IV) oxide / acetic acid; isopropyl alcohol / 16 h / 3750.38 Torr / sealed

4.1: triphenylphosphine / tetrahydrofuran / 0.17 h / 20 °C

4.2: 1.5 h / 20 °C

With dmap; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; platinum(IV) oxide; palladium 10% on activated carbon; In tetrahydrofuran; acetic acid; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;