ethyl [(3R)-5-methoxy-8-({[4-(trifluoromethyl)phenyl]amino}sulfonyl)-3,4-dihydro-2H-chromen-3-yl] carbamate

Base Information

Chemical Name:ethyl [(3R)-5-methoxy-8-({[4-(trifluoromethyl)phenyl]amino}sulfonyl)-3,4-dihydro-2H-chromen-3-yl] carbamate
CAS No.:916223-29-5
Molecular Formula:C₂₀H₂₁F₃N₂O₆S
Molecular Weight:474.458
Hs Code.:

Synonyms:ethyl [(3R)-5-methoxy-8-({[4-(trifluoromethyl)phenyl]amino}sulfonyl)-3,4-dihydro-2H-chromen-3-yl] carbamate

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Chemical Property of ethyl [(3R)-5-methoxy-8-({[4-(trifluoromethyl)phenyl]amino}sulfonyl)-3,4-dihydro-2H-chromen-3-yl] carbamate

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Technology Process of ethyl [(3R)-5-methoxy-8-({[4-(trifluoromethyl)phenyl]amino}sulfonyl)-3,4-dihydro-2H-chromen-3-yl] carbamate

There total 5 articles about ethyl [(3R)-5-methoxy-8-({[4-(trifluoromethyl)phenyl]amino}sulfonyl)-3,4-dihydro-2H-chromen-3-yl] carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: (3R)-3-amino-5-methoxy-N-[4-(trifluoromethyl)phenyl]chromane-8-sulfonamide

: 541-41-3
chloroformic acid ethyl ester

: 916223-29-5
ethyl [(3R)-5-methoxy-8-({[4-(trifluoromethyl)phenyl]amino}sulfonyl)-3,4-dihydro-2H-chromen-3-yl] carbamate

Guidance literature:: (3R)-3-amino-5-methoxy-N-[4-(trifluoromethyl)phenyl]chromane-8-sulfonamide; chloroformic acid ethyl ester; With pyridine; In dichloromethane; for 1h;

chloroformic acid ethyl ester; With pyridine; In dichloromethane; for 1h;

Reference yield:

: 916223-31-9
2,2,2-trifluoro-N-[(3R)-5-methoxy-8-({[4-(trifluoromethyl)phenyl]amino}sulfonyl)-3,4-dihydro-2H-chromen-3-yl]acetamide

: 916223-29-5
ethyl [(3R)-5-methoxy-8-({[4-(trifluoromethyl)phenyl]amino}sulfonyl)-3,4-dihydro-2H-chromen-3-yl] carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonia / methanol / 0.33 h / 140 °C / Microwave

2.1: pyridine / dichloromethane / 1 h

2.2: 1 h

With pyridine; ammonia; In methanol; dichloromethane;

Reference yield:

: 455-14-1
4-trifluoromethylphenylamine

: 916223-29-5
ethyl [(3R)-5-methoxy-8-({[4-(trifluoromethyl)phenyl]amino}sulfonyl)-3,4-dihydro-2H-chromen-3-yl] carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / dichloromethane / 8 h

2.1: ammonia / methanol / 0.33 h / 140 °C / Microwave

3.1: pyridine / dichloromethane / 1 h

3.2: 1 h

With pyridine; ammonia; In methanol; dichloromethane;