2-(5-{[(2S)-2-amino-3-(3-chlorophenyl)propyl]oxy}pyridin-3-yl)-N-hydroxy-8,9-dimethoxybenzo[c][2,7]naphthyridin-4-amine

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Chemical Name:2-(5-{[(2S)-2-amino-3-(3-chlorophenyl)propyl]oxy}pyridin-3-yl)-N-hydroxy-8,9-dimethoxybenzo[c][2,7]naphthyridin-4-amine
CAS No.:1055962-73-6
Molecular Formula:C₂₈H₂₆ClN₅O₄
Molecular Weight:531.999
Hs Code.:

Synonyms:2-(5-{[(2S)-2-amino-3-(3-chlorophenyl)propyl]oxy}pyridin-3-yl)-N-hydroxy-8,9-dimethoxybenzo[c][2,7]naphthyridin-4-amine

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Chemical Property of 2-(5-{[(2S)-2-amino-3-(3-chlorophenyl)propyl]oxy}pyridin-3-yl)-N-hydroxy-8,9-dimethoxybenzo[c][2,7]naphthyridin-4-amine

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Technology Process of 2-(5-{[(2S)-2-amino-3-(3-chlorophenyl)propyl]oxy}pyridin-3-yl)-N-hydroxy-8,9-dimethoxybenzo[c][2,7]naphthyridin-4-amine

There total 5 articles about 2-(5-{[(2S)-2-amino-3-(3-chlorophenyl)propyl]oxy}pyridin-3-yl)-N-hydroxy-8,9-dimethoxybenzo[c][2,7]naphthyridin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4101-30-8
2-amino-4,5-dimethoxyacetophenone

: 1055962-73-6
2-(5-{[(2S)-2-amino-3-(3-chlorophenyl)propyl]oxy}pyridin-3-yl)-N-hydroxy-8,9-dimethoxybenzo[c][2,7]naphthyridin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium acetate / 10 h / 165 °C / Heating / reflux

2.1: trichlorophosphate / 12 h / Heating / reflux

3.1: potassium carbonate / tetrahydrofuran; water / 6 h

3.2: 10 h / 2585.81 Torr

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 2.75 h / -78 - 20 °C

5.1: hydroxylamine hydrochloride / N,N-dimethyl-formamide / 18 h / 40 °C

5.2: 2 h / 20 °C

With hydroxylamine hydrochloride; ammonium acetate; potassium carbonate; lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 1055970-76-7
C₃₃H₃₃ClN₄O₆

: 1055962-73-6
2-(5-{[(2S)-2-amino-3-(3-chlorophenyl)propyl]oxy}pyridin-3-yl)-N-hydroxy-8,9-dimethoxybenzo[c][2,7]naphthyridin-4-amine

Guidance literature:: C₃₃H₃₃ClN₄O₆; With hydroxylamine hydrochloride; In N,N-dimethyl-formamide; at 40 ℃; for 18h;

With triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1055962-40-7
6,7-dimethoxy-4-methyl-3-cyanoquinoline

: 1055962-73-6
2-(5-{[(2S)-2-amino-3-(3-chlorophenyl)propyl]oxy}pyridin-3-yl)-N-hydroxy-8,9-dimethoxybenzo[c][2,7]naphthyridin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 2.75 h / -78 - 20 °C

2.1: hydroxylamine hydrochloride / N,N-dimethyl-formamide / 18 h / 40 °C

2.2: 2 h / 20 °C

With hydroxylamine hydrochloride; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;