N-{5-[(5-aminopyridin-2-yl)(methyl)amino]-2-fluorophenyl}-2,2,2-trifluoroacetamide

Base Information

Chemical Name:N-{5-[(5-aminopyridin-2-yl)(methyl)amino]-2-fluorophenyl}-2,2,2-trifluoroacetamide
CAS No.:1125632-82-7
Molecular Formula:C₁₄H₁₂F₄N₄O
Molecular Weight:328.269
Hs Code.:

Synonyms:N-{5-[(5-aminopyridin-2-yl)(methyl)amino]-2-fluorophenyl}-2,2,2-trifluoroacetamide

Suppliers and Price of N-{5-[(5-aminopyridin-2-yl)(methyl)amino]-2-fluorophenyl}-2,2,2-trifluoroacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{5-[(5-aminopyridin-2-yl)(methyl)amino]-2-fluorophenyl}-2,2,2-trifluoroacetamide

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Technology Process of N-{5-[(5-aminopyridin-2-yl)(methyl)amino]-2-fluorophenyl}-2,2,2-trifluoroacetamide

There total 8 articles about N-{5-[(5-aminopyridin-2-yl)(methyl)amino]-2-fluorophenyl}-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1125632-81-6
2,2,2-trifluoro-N-{2-fluoro-5-[methyl(5-nitropyridin-2-yl)amino]phenyl}acetamide

: 1125632-82-7
N-{5-[(5-aminopyridin-2-yl)(methyl)amino]-2-fluorophenyl}-2,2,2-trifluoroacetamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; at 20 ℃; for 14h; under 760.051 Torr;

Reference yield:

: 332370-72-6
N-(tert-butoxycarbonyl)-4-fluoro-3-nitroaniline

: 1125632-82-7
N-{5-[(5-aminopyridin-2-yl)(methyl)amino]-2-fluorophenyl}-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 6 steps

1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 20 °C / 760.05 Torr

3: tetrahydrofuran / 18 h / 4 - 10 °C

4: trifluoroacetic acid / 2 h / 4 - 10 °C

5: N,N-dimethyl-formamide / 22 h / 140 °C

6: hydrogen / palladium 10% on activated carbon / ethanol; tetrahydrofuran / 14 h / 20 °C / 760.05 Torr

With hydrogen; caesium carbonate; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 4548-45-2
2-chloro-5-nitropyridine

: 1125632-82-7
N-{5-[(5-aminopyridin-2-yl)(methyl)amino]-2-fluorophenyl}-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 22 h / 140 °C

2: hydrogen / palladium 10% on activated carbon / ethanol; tetrahydrofuran / 14 h / 20 °C / 760.05 Torr

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;