N-{5-[{4-fluoro-3-[(trifluoroacetyl)amino]phenyl}(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide

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Chemical Name:N-{5-[{4-fluoro-3-[(trifluoroacetyl)amino]phenyl}(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide
CAS No.:1125632-84-9
Molecular Formula:C₁₉H₁₅F₄N₅O₂S
Molecular Weight:453.42
Hs Code.:

Synonyms:N-{5-[{4-fluoro-3-[(trifluoroacetyl)amino]phenyl}(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide

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Chemical Property of N-{5-[{4-fluoro-3-[(trifluoroacetyl)amino]phenyl}(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide

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Technology Process of N-{5-[{4-fluoro-3-[(trifluoroacetyl)amino]phenyl}(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide

There total 11 articles about N-{5-[{4-fluoro-3-[(trifluoroacetyl)amino]phenyl}(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1125632-83-8
N-{5-[(2-amino[1,3]thiazolo[5,4-b]pyridin-5-yl)(methyl)amino]-2-fluorophenyl}-2,2,2-trifluoroacetamide

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1125632-84-9
N-{5-[{4-fluoro-3-[(trifluoroacetyl)amino]phenyl}(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide

Guidance literature:: With pyridine; at 4 - 20 ℃; for 1h;

Reference yield:

: 332370-72-6
N-(tert-butoxycarbonyl)-4-fluoro-3-nitroaniline

: 1125632-84-9
N-{5-[{4-fluoro-3-[(trifluoroacetyl)amino]phenyl}(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 20 °C / 760.05 Torr

3.1: tetrahydrofuran / 18 h / 4 - 10 °C

4.1: trifluoroacetic acid / 2 h / 4 - 10 °C

5.1: N,N-dimethyl-formamide / 22 h / 140 °C

6.1: hydrogen / palladium 10% on activated carbon / ethanol; tetrahydrofuran / 14 h / 20 °C / 760.05 Torr

7.1: acetic acid / 0.17 h / 20 °C

7.2: 0.17 h / 20 °C

8.1: bromine; acetic acid / 20 h / 20 °C

9.1: pyridine / 1 h / 4 - 20 °C

With pyridine; hydrogen; bromine; caesium carbonate; acetic acid; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 4548-45-2
2-chloro-5-nitropyridine

: 1125632-84-9
N-{5-[{4-fluoro-3-[(trifluoroacetyl)amino]phenyl}(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N-dimethyl-formamide / 22 h / 140 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol; tetrahydrofuran / 14 h / 20 °C / 760.05 Torr

3.1: acetic acid / 0.17 h / 20 °C

3.2: 0.17 h / 20 °C

4.1: bromine; acetic acid / 20 h / 20 °C

5.1: pyridine / 1 h / 4 - 20 °C

With pyridine; hydrogen; bromine; acetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;