(S)-2-(3-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenoxy)propan-1-ol

Base Information

Chemical Name:(S)-2-(3-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenoxy)propan-1-ol
CAS No.:1352571-46-0
Molecular Formula:C₂₉H₃₀N₂O₇S
Molecular Weight:550.632
Hs Code.:

Synonyms:(S)-2-(3-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenoxy)propan-1-ol

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Chemical Property of (S)-2-(3-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenoxy)propan-1-ol

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Technology Process of (S)-2-(3-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenoxy)propan-1-ol

There total 9 articles about (S)-2-(3-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenoxy)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 455-15-2
1-(methylsufonyl)-4-fluorobenzene

: 1352571-29-9
(S)-3-(1-(tert-butyldimethylsilyloxy)propan-2-yloxy)-5-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)phenol

: 1352571-46-0
(S)-2-(3-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenoxy)propan-1-ol

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; Sealed tube;

Reference yield:

: 136-36-7
benzoate d'hydroxy-3 phenyle

: 1352571-46-0
(S)-2-(3-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenoxy)propan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / -20 - 20 °C

2.2: 1 h / 0 °C / Reflux

3.1: 1H-imidazole / dichloromethane / 0.75 h / 0 - 20 °C

4.1: 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tert-butyl methyl ether / 10 h / 100 °C / Inert atmosphere; Microwave irradiation; Sealed tube

5.1: water; sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation; Sealed tube

6.1: potassium carbonate / N,N-dimethyl-formamide / 120 °C / Sealed tube

With 1H-imidazole; lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; water; sodium carbonate; potassium carbonate; triphenylphosphine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; dichloromethane; tert-butyl methyl ether; N,N-dimethyl-formamide; acetonitrile; 1.1: Mitsunobu reaction / 5.1: Suzuki Coupling;

Reference yield:

: 105-13-5
4-Methoxybenzyl alcohol

: 1352571-46-0
(S)-2-(3-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)-5-(4-(methylsulfonyl)phenoxy)phenoxy)propan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / toluene / 2.5 h / -25 °C

2: water; sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation; Sealed tube

3: potassium carbonate / N,N-dimethyl-formamide / 120 °C / Sealed tube

With water; sodium carbonate; potassium carbonate; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; toluene; acetonitrile; 2: Suzuki Coupling;