2-[3-chloro-4-(2-methylene-1-oxopropyl)phenoxymethyl]-4-(4-trifluoromethylphenyl)thiazole

Base Information

• Chemical Name: 2-[3-chloro-4-(2-methylene-1-oxopropyl)phenoxymethyl]-4-(4-trifluoromethylphenyl)thiazole
• CAS No.: 1370243-95-0
• Molecular Formula: C₂₁H₁₅ClF₃NO₂S
• Molecular Weight: 437.87
• Mol file: 1370243-95-0.mol

Synonyms:2-[3-chloro-4-(2-methylene-1-oxopropyl)phenoxymethyl]-4-(4-trifluoromethylphenyl)thiazole

Chemical Property of 2-[3-chloro-4-(2-methylene-1-oxopropyl)phenoxymethyl]-4-(4-trifluoromethylphenyl)thiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[3-chloro-4-(2-methylene-1-oxopropyl)phenoxymethyl]-4-(4-trifluoromethylphenyl)thiazole

There total 8 articles about 2-[3-chloro-4-(2-methylene-1-oxopropyl)phenoxymethyl]-4-(4-trifluoromethylphenyl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C23H22ClF3N2O2S → 2-[3-chloro-4-(2-methylene-1-oxopropyl)phenoxymethyl]-4-(4-trifluoromethylphenyl)thiazole (1370243-95-0)

Guidance literature:

With sodium hydrogencarbonate; In water; at 85 ℃; for 0.666667h;

DOI:10.1016/j.bmc.2012.02.011

Reference yield:

2-(3-chlorophenoxy)acetamide (35368-69-5) → 2-[3-chloro-4-(2-methylene-1-oxopropyl)phenoxymethyl]-4-(4-trifluoromethylphenyl)thiazole (1370243-95-0)

Guidance literature:

Multi-step reaction with 5 steps

1: tetraphosphorus decasulfide / tetrahydrofuran / 1.5 h / 50 °C

2: aluminum (III) chloride / carbon disulfide / 4.5 h / 20 - 50 °C

3: methanol / 24 h / Reflux

4: acetic acid / 1.5 h / 100 °C

5: sodium hydrogencarbonate / water / 0.67 h / 85 °C

With aluminum (III) chloride; tetraphosphorus decasulfide; sodium hydrogencarbonate; acetic acid; In tetrahydrofuran; methanol; carbon disulfide; water; 2: Friedel-Crafts acylation / 4: Mannich reaction;

DOI:10.1016/j.bmc.2012.02.011

Reference yield:

2-[3-chloro-4-(1-oxopropyl)phenoxymethyl]-4-(4-trifluoromethylphenyl)thiazole (1370244-31-7) → 2-[3-chloro-4-(2-methylene-1-oxopropyl)phenoxymethyl]-4-(4-trifluoromethylphenyl)thiazole (1370243-95-0)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / 1.5 h / 100 °C

2: sodium hydrogencarbonate / water / 0.67 h / 85 °C

With sodium hydrogencarbonate; acetic acid; In water; 1: Mannich reaction;

DOI:10.1016/j.bmc.2012.02.011

upstream raw materials:

2-[3-chloro-4-(1-oxopropyl)phenoxymethyl]-4-(4-trifluoromethylphenyl)thiazole

1-(4-trifluoromethylphenyl)ethanone

2-(3-chlorophenoxy)acetyl chloride

3-chlorophenoxyacetic acid