2-[3-chloro-4-(1-oxopropyl)phenoxymethyl]-4-(4-trifluoromethylphenyl)thiazole

Base Information

Chemical Name:2-[3-chloro-4-(1-oxopropyl)phenoxymethyl]-4-(4-trifluoromethylphenyl)thiazole
CAS No.:1370244-31-7
Molecular Formula:C₂₀H₁₅ClF₃NO₂S
Molecular Weight:425.859
Hs Code.:

Synonyms:2-[3-chloro-4-(1-oxopropyl)phenoxymethyl]-4-(4-trifluoromethylphenyl)thiazole

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Chemical Property of 2-[3-chloro-4-(1-oxopropyl)phenoxymethyl]-4-(4-trifluoromethylphenyl)thiazole

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Technology Process of 2-[3-chloro-4-(1-oxopropyl)phenoxymethyl]-4-(4-trifluoromethylphenyl)thiazole

There total 5 articles about 2-[3-chloro-4-(1-oxopropyl)phenoxymethyl]-4-(4-trifluoromethylphenyl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.5%

: 1370244-41-9
2-[3-chloro-4-(1-oxo-propyl)phenoxy]ethanethioamide

: 383-53-9
2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone

: 1370244-31-7
2-[3-chloro-4-(1-oxopropyl)phenoxymethyl]-4-(4-trifluoromethylphenyl)thiazole

Guidance literature:: In methanol; for 24h; Reflux;
DOI:10.1016/j.bmc.2012.02.011

Reference yield:

: 709-63-7
1-(4-trifluoromethylphenyl)ethanone

: 1370244-31-7
2-[3-chloro-4-(1-oxopropyl)phenoxymethyl]-4-(4-trifluoromethylphenyl)thiazole

Guidance literature:: Multi-step reaction with 2 steps

1: copper(ll) bromide / chloroform; ethyl acetate / 60 °C

2: methanol / 24 h / Reflux

With copper(ll) bromide; In methanol; chloroform; ethyl acetate;
DOI:10.1016/j.bmc.2012.02.011

Reference yield:

: 114476-84-5
2-(3-chlorophenoxy)acetyl chloride

: 1370244-31-7
2-[3-chloro-4-(1-oxopropyl)phenoxymethyl]-4-(4-trifluoromethylphenyl)thiazole

Guidance literature:: Multi-step reaction with 4 steps

1: ammonia / water; toluene / 1.5 h / 0 - 5 °C

2: tetraphosphorus decasulfide / tetrahydrofuran / 1.5 h / 50 °C

3: aluminum (III) chloride / carbon disulfide / 4.5 h / 20 - 50 °C

4: methanol / 24 h / Reflux

With aluminum (III) chloride; tetraphosphorus decasulfide; ammonia; In tetrahydrofuran; methanol; carbon disulfide; water; toluene; 3: Friedel-Crafts acylation;
DOI:10.1016/j.bmc.2012.02.011