35368-69-5

Basic information

• Product Name: 2-(3-CHLOROPHENOXY)ACETAMIDE
• Synonyms: 2-(3-CHLOROPHENOXY)ACETAMIDE;3-CHLOROPHENOXYACETAMIDE
• CAS NO: 35368-69-5
• Molecular Formula: C₈H₈ClNO₂
• Molecular Weight: 185.61
• Mol File: 35368-69-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 123 °C
• Boiling Point: 374.2°C at 760 mmHg
• Flash Point: 180.1°C
• Appearance: /
• Density: 1.3g/cm³
• Vapor Pressure: 8.49E-06mmHg at 25°C
• Refractive Index: 1.558
• CAS DataBase Reference: 2-(3-CHLOROPHENOXY)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-CHLOROPHENOXY)ACETAMIDE(35368-69-5)
• EPA Substance Registry System: 2-(3-CHLOROPHENOXY)ACETAMIDE(35368-69-5)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 35368-69-5(Hazardous Substances Data)

Usage

General Description

2-(3-chlorophenoxy)acetamide is a chemical compound with the molecular formula C8H8ClNO2. It is an amide derivative of 3-chlorophenol and is commonly used as an herbicide and pesticide. It functions by interfering with the growth and reproduction of unwanted plants and pests. The compound is also used in laboratory settings as a reagent for various chemical reactions. It is important to handle this chemical with care, as it may have harmful effects if inhaled, ingested, or comes into contact with the skin or eyes. Additionally, proper disposal and handling procedures should be followed to minimize any potential environmental impact.

InChI:InChI=1/C8H8ClNO2/c9-6-2-1-3-7(4-6)12-5-8(10)11/h1-4H,5H2,(H2,10,11)

Upstream product

• 108-43-0 3-monochlorophenol 
• 79-07-2 Chloroacetamide 
• 683-57-8 bromo-acetic acid amide 
• 588-32-9 3-chlorophenoxyacetic acid 
• 114476-84-5 2-(3-chlorophenoxy)acetyl chloride 

Downstream Products

• 35370-95-7 2-(3-chlorophenoxy) ethanethioamide 
• 1370243-95-0 2-[3-chloro-4-(2-methylene-1-oxopropyl)phenoxymethyl]-4-(4-trifluoromethylphenyl)thiazole 
• 1370243-93-8 2-[3-chloro-4-(2-methylene-1-oxopropyl)phenoxymethyl]-4-(naphthalen-2-yl)thiazole 
• 1370244-21-5 2-[3-chloro-4-(1-oxobutyl)phenoxymethyl]-4-(4-nitrophenyl)thiazole 
• 1370244-05-5 2-[3-chloro-4-(1-oxopropyl)phenoxymethyl]-4-phenylthiazole 
• 1370244-46-4 2-[3-chloro-4-(1-oxo-butyl)phenoxy]ethanethioamide 
• 1370244-41-9 2-[3-chloro-4-(1-oxo-propyl)phenoxy]ethanethioamide 
• 588-32-9 3-chlorophenoxyacetic acid 

Relevant articles and documents

A phenoxy acetyl amine compound preparation method and phenoxy acetamide compounds

The invention belongs to the organic intermediates and the technical field of pharmaceutical intermediates, in particular to a phenoxy acetyl amine compound preparation method and phenoxy acetyl amine compound. The present invention provides a preparation method of the pervasive should be good, and green environmental protection, has better popularization and application value. The results show that the embodiment, the invention provides the above-mentioned method can prepare a plurality of phenoxy acetyl amine compound, and the yield can be 76%.

Nitrogenous Heterocyclic Derivatives And Their Application In Drugs

The present invention relates to the field of medicine, provided herein are novel nitrogenous heterocyclic compounds, their preparation methods and their uses as drugs, especially for treatment and prevention of tissue fibrosis. Also provided herein are pharmaceutically acceptable compositions comprising the nitrogenous heterocyclic compounds and the uses of the compositions in the treatment of human or animal tissue fibrosis, especially for human or animal renal interstitial fibrosis, glomerular sclerosis, liver fibrosis, pulmonary fibrosis, peritoneal fibrosis, myocardial fibrosis, dermatofibrosis, postsurgical adhesion, benign prostatic hyperplasia, skeletal muscle fibrosis, scleroderma, multiple sclerosis, pancreatic fibrosis, cirrhosis, myosarcoma, neurofibroma, pulmonary interstitial fibrosis, diabetic nephropathy, alzheimer disease or vascular fibrosis.

The synthesis of ethacrynic acid thiazole derivatives as glutathione S-transferase pi inhibitors

Glutathione S-transferase pi (GSTpi) is a phase II enzyme which protects cells from death and detoxifies chemotherapeutic agents in cancer cells. Ethacrynic acid (EA) is a weak GSTpi inhibitor. Structure modifications were done to improve the ability of EA to inhibit GSTpi activity. Eighteen EA thiazole derivatives were designed and synthesized. Compounds 9a, 9b and 9c with a replacement of carboxyl group of EA by a heterocyclic thiazole exhibited improvement over EA to inhibit GSTpi activity.