1-<<(diphenyl-tert-butylsilyl)oxy>methyl>-1-methyl-2-<(pivaloyloxy)methyl>-3,4-dihydroxy-1,2,3,4,5,6,7,8-octahydronaphthalene

Base Information

Chemical Name:1-<<(diphenyl-tert-butylsilyl)oxy>methyl>-1-methyl-2-<(pivaloyloxy)methyl>-3,4-dihydroxy-1,2,3,4,5,6,7,8-octahydronaphthalene
CAS No.:143121-43-1
Molecular Formula:C₃₄H₄₈O₅Si
Molecular Weight:564.838
Hs Code.:

Synonyms:1-<<(diphenyl-tert-butylsilyl)oxy>methyl>-1-methyl-2-<(pivaloyloxy)methyl>-3,4-dihydroxy-1,2,3,4,5,6,7,8-octahydronaphthalene

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Chemical Property of 1-<<(diphenyl-tert-butylsilyl)oxy>methyl>-1-methyl-2-<(pivaloyloxy)methyl>-3,4-dihydroxy-1,2,3,4,5,6,7,8-octahydronaphthalene

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Technology Process of 1-<<(diphenyl-tert-butylsilyl)oxy>methyl>-1-methyl-2-<(pivaloyloxy)methyl>-3,4-dihydroxy-1,2,3,4,5,6,7,8-octahydronaphthalene

There total 4 articles about 1-<<(diphenyl-tert-butylsilyl)oxy>methyl>-1-methyl-2-<(pivaloyloxy)methyl>-3,4-dihydroxy-1,2,3,4,5,6,7,8-octahydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 143121-42-0
1-<<(diphenyl-tert-butylsilyl)oxy>methyl>-1-methyl-2-<(pivaloyloxy)methyl>-1,2,5,6,7,8-hexahydronaphthalene

: 143121-43-1
1-<<(diphenyl-tert-butylsilyl)oxy>methyl>-1-methyl-2-<(pivaloyloxy)methyl>-3,4-dihydroxy-1,2,3,4,5,6,7,8-octahydronaphthalene

Guidance literature:: With 4-methylmorpholine N-oxide; osmium(VIII) oxide; In water; acetone; at 25 ℃; for 48h;
DOI:10.1021/jo00044a025

Reference yield:

: 3282-30-2
pivaloyl chloride

: 143121-43-1
1-<<(diphenyl-tert-butylsilyl)oxy>methyl>-1-methyl-2-<(pivaloyloxy)methyl>-3,4-dihydroxy-1,2,3,4,5,6,7,8-octahydronaphthalene

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / pyridine / CH₂Cl₂ / 1 h / -30 °C

2: 96 percent / imidazole / dimethylformamide / a) 0 deg C, 15 min, b) 70 deg C, 15 h

3: 64 percent / 4-methyl-morpholine N-oxide / osmium tetroxide / acetone; H₂O / 48 h / 25 °C

With pyridine; 1H-imidazole; 4-methylmorpholine N-oxide; osmium(VIII) oxide; In dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00044a025

Reference yield:

: 143121-39-5
((1R,2R)-2-Hydroxymethyl-1-methyl-1,2,5,6,7,8-hexahydro-naphthalen-1-yl)-methanol

: 143121-43-1
1-<<(diphenyl-tert-butylsilyl)oxy>methyl>-1-methyl-2-<(pivaloyloxy)methyl>-3,4-dihydroxy-1,2,3,4,5,6,7,8-octahydronaphthalene

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / pyridine / CH₂Cl₂ / 1 h / -30 °C

2: 96 percent / imidazole / dimethylformamide / a) 0 deg C, 15 min, b) 70 deg C, 15 h

3: 64 percent / 4-methyl-morpholine N-oxide / osmium tetroxide / acetone; H₂O / 48 h / 25 °C

With pyridine; 1H-imidazole; 4-methylmorpholine N-oxide; osmium(VIII) oxide; In dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo00044a025