4'-methyl-N-((6-methylpyridin-3-yl)methyl)-5-(4-(thiazol-2-yl)piperazine-1-carbonyl)biphenyl-3-carboxamide

Base Information

Chemical Name:4'-methyl-N-((6-methylpyridin-3-yl)methyl)-5-(4-(thiazol-2-yl)piperazine-1-carbonyl)biphenyl-3-carboxamide
CAS No.:1186515-70-7
Molecular Formula:C₂₉H₂₉N₅O₂S
Molecular Weight:511.648
Hs Code.:

Synonyms:4'-methyl-N-((6-methylpyridin-3-yl)methyl)-5-(4-(thiazol-2-yl)piperazine-1-carbonyl)biphenyl-3-carboxamide

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Chemical Property of 4'-methyl-N-((6-methylpyridin-3-yl)methyl)-5-(4-(thiazol-2-yl)piperazine-1-carbonyl)biphenyl-3-carboxamide

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Technology Process of 4'-methyl-N-((6-methylpyridin-3-yl)methyl)-5-(4-(thiazol-2-yl)piperazine-1-carbonyl)biphenyl-3-carboxamide

There total 6 articles about 4'-methyl-N-((6-methylpyridin-3-yl)methyl)-5-(4-(thiazol-2-yl)piperazine-1-carbonyl)biphenyl-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42270-37-1
1-thiazol-2-yl-piperazine

: 1186515-28-5
4'-methyl-5-((6-methylpyridin-3-yl)methylcarbamoyl)biphenyl-3-carboxylic acid

: 1186515-70-7
4'-methyl-N-((6-methylpyridin-3-yl)methyl)-5-(4-(thiazol-2-yl)piperazine-1-carbonyl)biphenyl-3-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 25 ℃; for 16h;

Reference yield:

: 51760-21-5
dimethyl 5-bromoisophthalate

: 1186515-70-7
4'-methyl-N-((6-methylpyridin-3-yl)methyl)-5-(4-(thiazol-2-yl)piperazine-1-carbonyl)biphenyl-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 6 h / Reflux

2.1: lithium hydroxide / 1,4-dioxane / 20 °C

2.2: pH 2 - 3

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C

4.1: water; lithium hydroxide / ethanol / 20 °C

4.2: pH 4

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 25 °C

With water; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 5720-05-8
4-methylphenylboronic acid

: 1186515-70-7
4'-methyl-N-((6-methylpyridin-3-yl)methyl)-5-(4-(thiazol-2-yl)piperazine-1-carbonyl)biphenyl-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 6 h / Reflux

2.1: lithium hydroxide / 1,4-dioxane / 20 °C

2.2: pH 2 - 3

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C

4.1: water; lithium hydroxide / ethanol / 20 °C

4.2: pH 4

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 25 °C

With water; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;