42270-37-1

Basic information

• Product Name: 1-(2-Thiazolyl)piperazine
• Synonyms: 1-(1,3-THIAZOL-2-YL)PIPERAZINE;Piperazine, 1-(2-thiazolyl)- (9CI);1-(2-thiazolyl)piperazine;1-THIAZOL-2-YL-PIPERAZINE >98%;Piperazine, 1-(2-thiazolyl)-;2-(Piperazin-1-yl)thiazole;2-(Piperazin-1-yl)-1,3-thiazole;1-(thiazol-2-yl)piperazine hydrochloride
• CAS NO: 42270-37-1
• Molecular Formula: C₇H₁₁N₃S
• Molecular Weight: 169.25
• EINECS: 255-743-5
• Product Categories: PIPERIDINE;pharmacetical;piperazines
• Mol File: 42270-37-1.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 96 °C
• Flash Point: 131.1 °C
• Appearance: /
• Density: 1.205 g/cm³
• Vapor Pressure: 0.00176mmHg at 25°C
• Refractive Index: 1.573
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 8.40±0.10(Predicted)
• CAS DataBase Reference: 1-(2-Thiazolyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Thiazolyl)piperazine(42270-37-1)
• EPA Substance Registry System: 1-(2-Thiazolyl)piperazine(42270-37-1)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 42270-37-1(Hazardous Substances Data)

Usage

Uses

1-Thiazol-2-yl-piperazine is used to study anti-HIV 6-Desfluoroquinolones.

InChI:InChI=1/C7H11N3S/c1-4-10(5-2-8-1)7-9-3-6-11-7/h3,6,8H,1-2,4-5H2

Upstream product

• 110-85-0 piperazine 
• 3034-53-5 2-bromo-1,3-thiazole 
• 474417-23-7 tert-butyl 4-(thiazol-2-yl)piperazine-1-carboxylate 
• 3034-52-4 2-chlorothiazole 
• 7542-23-6 piperazine hydrochloride 
• 142-64-3 piperazine dihydrochloride 

Downstream Products

• 54998-49-1 4-nitro-N-[2-(4-thiazol-2-yl-piperazin-1-yl)-ethyl]-benzamide 
• 17766-79-9 1-thiazol-2-yl-4-(3,4,5-trimethoxy-benzoyl)-piperazine 
• 861965-29-9 1-phenyl-3-[4-(1,3-thiazol-2-yl)piperazin-1-yl]propan-1-one 
• 1203799-91-0 4-[(7-chloroquinolin-4-yl)amino]-2-{[4-(1,3-thiazol-2-yl)piperazin-1-yl]methyl}phenol 
• 1095535-16-2 (1R,2R)-N-(1-cyanocyclopropyl)-2-{[4-(1,3-thiazol-2-yl)piperazin-1-yl]carbonyl}cyclohexanecarboxamide 
• 354587-77-2 tert-butyl 4-(5-formylthiazol-2-yl)piperazine-1-carboxylate 

Relevant articles and documents

Base Catalysis Enables Access to α,α-Difluoroalkylthioethers

A nucleophilic addition reaction of aryl thiols to readily available β,β-difluorostyrenes provides α,α-difluoroalkylthioethers. The reaction proceeds through an unstable anionic intermediate, prone to eliminate fluoride and generate α-fluorovinylthioethers. However, the use of base catalysis overcomes the facile β-fluoride elimination, generating α,α-difluoroalkylthioethers in excellent yields and selectivities.

Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition

The discovery of nitrile compound 4, a potent inhibitor of Cathepsin K (Cat K) with good bioavailability in dog is described. The compound was used to demonstrate target engagement and inhibition of Cat K in an in vivo dog PD model. The margin to hERG ion channel inhibition was deemed too low for a clinical candidate and an optimisation program to find isosteres or substitutions on benzothiazole group led to the discovery of 20, 24 and 27; all three free from hERG inhibition.

Substituted Disulfonamide Compounds

Substituted disulfonamide compounds corresponding to formula I: In which R1, R2, R3, R4a, R4b, R5a, R5b, R8, R9a, R9b, R10, R11, a, b, s, t and A have defined meanings, pharmaceutical compositions containing one or more such compounds, processes for preparing such compounds, and a method of using such compounds for the treatment or inhibition of pain and/or other conditions mediated by the bradykinin receptor 1 (BR1).