1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-(dimethylmalonyl)-2,5-piperazinedione (syn)

Base Information

Chemical Name:1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-(dimethylmalonyl)-2,5-piperazinedione (syn)
CAS No.:95676-22-5
Molecular Formula:C₃₀H₃₁N₃O₈S
Molecular Weight:593.657
Hs Code.:

Synonyms:1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-(dimethylmalonyl)-2,5-piperazinedione (syn)

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Chemical Property of 1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-(dimethylmalonyl)-2,5-piperazinedione (syn)

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Technology Process of 1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-(dimethylmalonyl)-2,5-piperazinedione (syn)

There total 5 articles about 1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-(dimethylmalonyl)-2,5-piperazinedione (syn) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 92097-99-9
1,4-bis(4-methoxybenzyl)piperazine-2,5-dione

: 95676-22-5
1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-(dimethylmalonyl)-2,5-piperazinedione (syn)

Guidance literature:: Multi-step reaction with 3 steps

1: 90.2 percent / N-bromosuccinimide / benzoyl peroxide / CCl₄ / 2 h / Heating

2: 1.) NaH / 1.) THF, room temp., 30 min; 2.) THF, 30 min

3: silver triflate / tetrahydrofuran / 2 h / Ambient temperature

With N-Bromosuccinimide; silver trifluoromethanesulfonate; sodium hydride; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane;
DOI:10.1021/ja00297a034

Reference yield:

: 2746-25-0
p-Methoxybenzyl bromide

: 95676-22-5
1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-(dimethylmalonyl)-2,5-piperazinedione (syn)

Guidance literature:: Multi-step reaction with 4 steps

1: NaH / dimethylformamide / 25 °C

2: 90.2 percent / N-bromosuccinimide / benzoyl peroxide / CCl₄ / 2 h / Heating

3: 1.) NaH / 1.) THF, room temp., 30 min; 2.) THF, 30 min

4: silver triflate / tetrahydrofuran / 2 h / Ambient temperature

With N-Bromosuccinimide; silver trifluoromethanesulfonate; sodium hydride; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00297a034

Reference yield:

: 92098-10-7
3,6-dibromo-1,4-bis(4-methoxybenzyl)piperazine-2,5-dione

: 95676-22-5
1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-(dimethylmalonyl)-2,5-piperazinedione (syn)

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) THF, room temp., 30 min; 2.) THF, 30 min

2: silver triflate / tetrahydrofuran / 2 h / Ambient temperature

With silver trifluoromethanesulfonate; sodium hydride; In tetrahydrofuran;
DOI:10.1021/ja00297a034