4-hydroxy-7,8-dimethoxy-3-(4-methoxyphenyl)dibenzo[b,d]furan-1,2-diyl diacetate

Base Information

Chemical Name:4-hydroxy-7,8-dimethoxy-3-(4-methoxyphenyl)dibenzo[b,d]furan-1,2-diyl diacetate
CAS No.:1541073-45-3
Molecular Formula:C₂₅H₂₂O₉
Molecular Weight:466.444
Hs Code.:

Synonyms:4-hydroxy-7,8-dimethoxy-3-(4-methoxyphenyl)dibenzo[b,d]furan-1,2-diyl diacetate

Suppliers and Price of 4-hydroxy-7,8-dimethoxy-3-(4-methoxyphenyl)dibenzo[b,d]furan-1,2-diyl diacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-hydroxy-7,8-dimethoxy-3-(4-methoxyphenyl)dibenzo[b,d]furan-1,2-diyl diacetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-hydroxy-7,8-dimethoxy-3-(4-methoxyphenyl)dibenzo[b,d]furan-1,2-diyl diacetate

There total 15 articles about 4-hydroxy-7,8-dimethoxy-3-(4-methoxyphenyl)dibenzo[b,d]furan-1,2-diyl diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1541073-41-9
benzyl (1,2-dihydroxy-7,8-dimethoxy-3-(4-methoxyphenyl)dibenzo[b,d]furan-4-yl)carbonate

: 75-36-5
acetyl chloride

: 1541073-45-3
4-hydroxy-7,8-dimethoxy-3-(4-methoxyphenyl)dibenzo[b,d]furan-1,2-diyl diacetate

Guidance literature:: benzyl (1,2-dihydroxy-7,8-dimethoxy-3-(4-methoxyphenyl)dibenzo[b,d]furan-4-yl)carbonate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

acetyl chloride; In tetrahydrofuran; at -78 - 20 ℃;

With 10 wt% Pd(OH)2 on carbon; hydrogen; In ethyl acetate; for 16h;
DOI:10.1021/jo402492d

Reference yield:

: 1541073-33-9
8,9-dimethoxy-5-(methoxymethoxy)-4-(4-methoxyphenyl)-benzo[b][1,3]dioxolo[4,5-e]benzofuran

: 1541073-45-3
4-hydroxy-7,8-dimethoxy-3-(4-methoxyphenyl)dibenzo[b,d]furan-1,2-diyl diacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 2 h / 20 °C

2.1: pyridine / dichloromethane / 0.5 h / 0 °C

3.1: toluene / 2 h / Reflux

4.1: acetic acid / 0.5 h / 20 °C

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

5.2: -78 - 20 °C

5.3: 16 h

With pyridine; hydrogenchloride; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene;
DOI:10.1021/jo402492d

Reference yield:

: 1541073-30-6
4-(2-chloro-4,5-dimethoxyphenyl)-6-(methoxymethoxy)-7-(4-methoxyphenyl)benzo[d][1,3]dioxol-5-yl formate

: 1541073-45-3
4-hydroxy-7,8-dimethoxy-3-(4-methoxyphenyl)dibenzo[b,d]furan-1,2-diyl diacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: copper(I) oxide; pyridine / 16 h / Inert atmosphere; Reflux

2.1: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 2 h / 20 °C

3.1: pyridine / dichloromethane / 0.5 h / 0 °C

4.1: toluene / 2 h / Reflux

5.1: acetic acid / 0.5 h / 20 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

6.2: -78 - 20 °C

6.3: 16 h

With pyridine; copper(I) oxide; hydrogenchloride; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene; 1.1: |Ullmann Condensation;
DOI:10.1021/jo402492d