Technology Process of 8,9-dimethoxy-4-(4-methoxyphenyl)benzo[b][1,3]dioxolo-[4,5-e]benzofuran-5-ol
There total 11 articles about 8,9-dimethoxy-4-(4-methoxyphenyl)benzo[b][1,3]dioxolo-[4,5-e]benzofuran-5-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
tetrahydrofuran; 1,4-dioxane;
at 20 ℃;
for 2h;
DOI:10.1021/jo402492d
- Guidance literature:
-
Multi-step reaction with 2 steps
1: copper(I) oxide; pyridine / 16 h / Inert atmosphere; Reflux
2: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 2 h / 20 °C
With
pyridine; copper(I) oxide; hydrogenchloride;
In
tetrahydrofuran; 1,4-dioxane;
1: |Ullmann Condensation;
DOI:10.1021/jo402492d
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: bromine; acetic acid / 3 h
2.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C
2.2: -78 - 20 °C
2.3: 1 h
3.1: caesium carbonate; tetrakis(triphenylphosphine) palladium(0) / water; toluene / 16 h / Inert atmosphere; Reflux
4.1: caesium carbonate; tetrakis(triphenylphosphine) palladium(0) / water; toluene / 16 h / Inert atmosphere; Reflux
5.1: potassium fluoride; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C
6.1: copper(I) oxide; pyridine / 16 h / Inert atmosphere; Reflux
7.1: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 2 h / 20 °C
With
pyridine; copper(I) oxide; hydrogenchloride; potassium fluoride; tetrakis(triphenylphosphine) palladium(0); n-butyllithium; bromine; caesium carbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene;
3.1: |Suzuki-Miyaura Coupling / 4.1: |Suzuki-Miyaura Coupling / 5.1: |Baeyer-Villiger Ketone Oxidation / 6.1: |Ullmann Condensation;
DOI:10.1021/jo402492d