2,2-Dimethyl-propionic acid (S)-3-benzyloxymethoxy-4-oxo-pentyl ester

Base Information

• Chemical Name: 2,2-Dimethyl-propionic acid (S)-3-benzyloxymethoxy-4-oxo-pentyl ester
• CAS No.: 913643-40-0
• Molecular Formula: C₁₈H₂₆O₅
• Molecular Weight: 322.401
• Mol file: 913643-40-0.mol

Synonyms:2,2-Dimethyl-propionic acid (S)-3-benzyloxymethoxy-4-oxo-pentyl ester

Chemical Property of 2,2-Dimethyl-propionic acid (S)-3-benzyloxymethoxy-4-oxo-pentyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2,2-Dimethyl-propionic acid (S)-3-benzyloxymethoxy-4-oxo-pentyl ester

There total 3 articles about 2,2-Dimethyl-propionic acid (S)-3-benzyloxymethoxy-4-oxo-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pivaloyl chloride (3282-30-2) + (S)-3-Benzyloxymethoxy-5-hydroxy-pentan-2-one → 2,2-Dimethyl-propionic acid (S)-3-benzyloxymethoxy-4-oxo-pentyl ester (913643-40-0)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/ol061908i

Reference yield:

Benzyloxymethyl chloride (3587-60-8) → 2,2-Dimethyl-propionic acid (S)-3-benzyloxymethoxy-4-oxo-pentyl ester (913643-40-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / iPr₂NEt; nBu₄NI / tetrahydrofuran / 20 °C

2: tetrahydrofuran / -78 °C

3: pyridine / CH₂Cl₂ / 0 - 20 °C

With pyridine; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ol061908i

Reference yield:

(S)-3-hydroxybutyrolactone, benzyloxy methyl ether (73991-96-5) → 2,2-Dimethyl-propionic acid (S)-3-benzyloxymethoxy-4-oxo-pentyl ester (913643-40-0)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / -78 °C

2: pyridine / CH₂Cl₂ / 0 - 20 °C

With pyridine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ol061908i

upstream raw materials:

pivaloyl chloride

Benzyloxymethyl chloride

(S)-3-hydroxybutyrolactone, benzyloxy methyl ether