N-(((4-(4-chlorophenyl)-3-phenylisoquinolin-1-yl)(cyclohexyl)amino)(cyclohexylamino)methylene)-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-(((4-(4-chlorophenyl)-3-phenylisoquinolin-1-yl)(cyclohexyl)amino)(cyclohexylamino)methylene)-4-methylbenzenesulfonamide
CAS No.:1383274-48-3
Molecular Formula:C₄₁H₄₃ClN₄O₂S
Molecular Weight:691.337
Hs Code.:

Synonyms:N-(((4-(4-chlorophenyl)-3-phenylisoquinolin-1-yl)(cyclohexyl)amino)(cyclohexylamino)methylene)-4-methylbenzenesulfonamide

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Chemical Property of N-(((4-(4-chlorophenyl)-3-phenylisoquinolin-1-yl)(cyclohexyl)amino)(cyclohexylamino)methylene)-4-methylbenzenesulfonamide

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Technology Process of N-(((4-(4-chlorophenyl)-3-phenylisoquinolin-1-yl)(cyclohexyl)amino)(cyclohexylamino)methylene)-4-methylbenzenesulfonamide

There total 4 articles about N-(((4-(4-chlorophenyl)-3-phenylisoquinolin-1-yl)(cyclohexyl)amino)(cyclohexylamino)methylene)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1383274-27-8
N-(((4-bromo-3-phenylisoquinolin-1-yl)(cyclohexyl)amino)(cyclohexylamino)methylene)-4-methylbenzenesulfonamide

: 1679-18-1
4-Chlorophenylboronic acid

: 1383274-48-3
N-(((4-(4-chlorophenyl)-3-phenylisoquinolin-1-yl)(cyclohexyl)amino)(cyclohexylamino)methylene)-4-methylbenzenesulfonamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In water; N,N-dimethyl-formamide; at 70 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2012.03.081

Reference yield:

: 1112200-32-4
C₂₂H₁₇BrN₂O₂S

: 1383274-48-3
N-(((4-(4-chlorophenyl)-3-phenylisoquinolin-1-yl)(cyclohexyl)amino)(cyclohexylamino)methylene)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane; acetonitrile / 20 °C

2: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / water; N,N-dimethyl-formamide / 70 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 2: Suzuki-Miyaura coupling;
DOI:10.1016/j.tet.2012.03.081

Reference yield:

: 1576-35-8
toluene-4-sulfonic acid hydrazide

: 1383274-48-3
N-(((4-(4-chlorophenyl)-3-phenylisoquinolin-1-yl)(cyclohexyl)amino)(cyclohexylamino)methylene)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane / 0.5 h / 20 °C

2: 1,4-diaza-bicyclo[2.2.2]octane; bromine / dichloromethane / 0.17 h / 20 °C

3: dichloromethane; acetonitrile / 20 °C

4: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / water; N,N-dimethyl-formamide / 70 °C / Inert atmosphere

With 1,4-diaza-bicyclo[2.2.2]octane; bis-triphenylphosphine-palladium(II) chloride; bromine; potassium carbonate; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 4: Suzuki-Miyaura coupling;
DOI:10.1016/j.tet.2012.03.081