2,2-Dimethyl-propionic acid (R)-5-benzyloxy-1-((R)-1-methyl-2-phenyl-ethyl)-pentyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (R)-5-benzyloxy-1-((R)-1-methyl-2-phenyl-ethyl)-pentyl ester
CAS No.:171190-06-0
Molecular Formula:C₂₆H₃₆O₃
Molecular Weight:396.57
Hs Code.:

Synonyms:2,2-Dimethyl-propionic acid (R)-5-benzyloxy-1-((R)-1-methyl-2-phenyl-ethyl)-pentyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,2-Dimethyl-propionic acid (R)-5-benzyloxy-1-((R)-1-methyl-2-phenyl-ethyl)-pentyl ester

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Technology Process of 2,2-Dimethyl-propionic acid (R)-5-benzyloxy-1-((R)-1-methyl-2-phenyl-ethyl)-pentyl ester

There total 7 articles about 2,2-Dimethyl-propionic acid (R)-5-benzyloxy-1-((R)-1-methyl-2-phenyl-ethyl)-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 3282-30-2
pivaloyl chloride

: 171189-83-6
(2R,3R)-7-Benzyloxy-2-methyl-1-phenyl-heptan-3-ol

: 171190-06-0
2,2-Dimethyl-propionic acid (R)-5-benzyloxy-1-((R)-1-methyl-2-phenyl-ethyl)-pentyl ester

Guidance literature:: With dmap; In dichloromethane; for 16h; Heating;
DOI:10.1021/ja00136a008

Reference yield:

: 78999-24-3
5-benzyloxy-1-pentanal

: 171190-06-0
2,2-Dimethyl-propionic acid (R)-5-benzyloxy-1-((R)-1-methyl-2-phenyl-ethyl)-pentyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) 9-BBNOTf, i-Pr₂NEt / 1.) CH₂Cl₂, a) -78 deg C, 30 min, b) 0 deg C, 3 h, 2.) CH₂Cl₂, 23 deg C, 12 h

2: 17.5 g / aq. LiOH, 30percent aq. H₂O₂ / tetrahydrofuran / 3 h / 0 °C

3: 92 percent / LiAlH₄ / tetrahydrofuran / 8 h / Heating

4: 89 percent / pyridine / 42 h / 0 °C

5: PhLi / cyclohexane; diethyl ether / 0.5 h / 23 °C

6: BF₃*OEt₂ / cyclohexane; diethyl ether / 1 h / -78 - 0 °C

7: 90 percent / 4-DMAP / CH₂Cl₂ / 16 h / Heating

With pyridine; dmap; lithium hydroxide; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; dihydrogen peroxide; phenyllithium; N-ethyl-N,N-diisopropylamine; 9-BBN triflate; In tetrahydrofuran; diethyl ether; dichloromethane; cyclohexane;
DOI:10.1021/ja00136a008

Reference yield:

: (2R,3R)-2-(4-Benzyloxy-butyl)-3-methyl-oxetane

: 171190-06-0
2,2-Dimethyl-propionic acid (R)-5-benzyloxy-1-((R)-1-methyl-2-phenyl-ethyl)-pentyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: BF₃*OEt₂ / cyclohexane; diethyl ether / 1 h / -78 - 0 °C

2: 90 percent / 4-DMAP / CH₂Cl₂ / 16 h / Heating

With dmap; boron trifluoride diethyl etherate; In diethyl ether; dichloromethane; cyclohexane;
DOI:10.1021/ja00136a008