3-azidobenzyl chloride

Base Information

• Chemical Name: 3-azidobenzyl chloride
• CAS No.: 120692-80-0
• Molecular Formula: C₇H₆ClN₃
• Molecular Weight: 167.598
• Mol file: 120692-80-0.mol

Synonyms:3-azidobenzyl chloride

Chemical Property of 3-azidobenzyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-azidobenzyl chloride

There total 2 articles about 3-azidobenzyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-azido-3-hydroxymethylbenzene (89937-85-9) → 3-azidobenzyl chloride (120692-80-0)

Guidance literature:

With thionyl chloride; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1016/S0040-4039(98)01707-9

Reference yield:

3-aminobenzenemethanol (1877-77-6) → 3-azidobenzyl chloride (120692-80-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium nitrite; sulfuric acid / H₂O / 0.5 h / cooling

1.2: 82 percent / sodium azide / H₂O / 16 h / 20 °C

2.1: 86 percent / thionyl chloride / CH₂Cl₂ / 3 h / 0 °C

With thionyl chloride; sulfuric acid; sodium nitrite; In dichloromethane; water;

DOI:10.1016/j.tet.2006.04.056

Reference yield: 91.0%

3-azidobenzyl chloride (120692-80-0) → 3-azidobenzyl iodide (443299-18-1)

Guidance literature:

With sodium iodide; In acetone; at 20 ℃; for 12h;

DOI:10.1016/j.tet.2006.04.056

upstream raw materials:

1-azido-3-hydroxymethylbenzene

3-aminobenzenemethanol

Downstream raw materials:

tris(m-azidobenzyl)amine

bis(3-azidobenzyl)amine

m-azido benzyl amine

3-azidobenzyl iodide