N,N-Bis(2-hydroxyethyl)dodecanamide

Base Information

• Chemical Name: N,N-Bis(2-hydroxyethyl)dodecanamide
• CAS No.: 120-40-1
• Deprecated CAS: 15517-64-3,39341-48-5,83590-20-9,92680-75-6,83452-99-7,267663-44-5,267663-44-5,39341-48-5,83452-99-7,92680-75-6
• Molecular Formula: C16H33NO3
• Molecular Weight: 287.443
• Hs Code.: DERIVATION
• European Community (EC) Number: 204-393-1,277-136-4
• UNII: I29I2VHG38
• DSSTox Substance ID: DTXSID5025491,DTXSID101022608
• Nikkaji Number: J36.818K
• Wikidata: Q27280284
• NCI Thesaurus Code: C77472
• RXCUI: 1363705
• Metabolomics Workbench ID: 45457
• ChEMBL ID: CHEMBL1996872
• Mol file: 120-40-1.mol

Synonyms:lauramide DEA;lauramide diethanolamine;lauric acid diethanolamide

Chemical Property of N,N-Bis(2-hydroxyethyl)dodecanamide

Chemical Property:

• Appearance/Colour: Off-white waxy solid
• Vapor Pressure: 1.15E-08mmHg at 25°C
• Melting Point: 45-48℃
• Refractive Index: 1.478
• Boiling Point: 443.2 °C at 760 mmHg
• PKA: 14.13±0.10(Predicted)
• Flash Point: 221.9 °C
• PSA: 60.77000
• Density: 0.984 g/cm³
• LogP: 2.72050
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• Water Solubility.: 49.91mg/L at 20℃
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 14
• Exact Mass: 287.24604391
• Heavy Atom Count: 20
• Complexity: 216

Purity/Quality:

98% min ^*data from raw suppliers

N,N-Bis(2-hydroxyethyl)dodecanamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Other Nitrogen Compounds
• Canonical SMILES: CCCCCCCCCCCC(=O)N(CCO)CCO
• Recent ClinicalTrials: Treatment of Patients With Atherosclerotic Disease With Methotrexate-associated to LDL Like Nanoparticles
• Uses: N,N-Bis(2-hydroxyethyl)dodecanamide is used in preparation method of water-absorbent resin for improving anti-caking performance.

Technology Process of N,N-Bis(2-hydroxyethyl)dodecanamide

There total 12 articles about N,N-Bis(2-hydroxyethyl)dodecanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl n-dodecanoate (111-82-0) + 2,2'-iminobis[ethanol] (111-42-2) → N,N-bis-(2-hydroxy-ethyl)-lauramide (120-40-1)

Guidance literature:

at 110 ℃; for 1h; Reagent/catalyst; Catalytic behavior;

DOI:10.1039/c5nj00388a

Reference yield: 97.0%

lauric acid (143-07-7) + 2,2'-iminobis[ethanol] (111-42-2) → N,N-bis-(2-hydroxy-ethyl)-lauramide (120-40-1)

Guidance literature:

at 50 - 190 ℃; under 760.051 - 7500.75 Torr; Microwave irradiation;

Reference yield: 88.0%

n-dodecanoyl chloride (112-16-3) + 2,2'-iminobis[ethanol] (111-42-2) → N,N-bis-(2-hydroxy-ethyl)-lauramide (120-40-1)

Guidance literature:

In methanol; diethyl ether;

upstream raw materials:

2-(2-lauroyloxy-ethylamino)-ethanol

n-dodecanoyl chloride

2,2'-iminobis[ethanol]

ethyl laurate

Downstream raw materials:

N,N-Bis-(2-lauroyloxyethyl)-lauramid

2-(2-lauroyloxy-ethylamino)-ethanol

N,n-bis(2-trimethylacetoxyethyl)lauramide

N,n-bis(2-benzoyloxyethyl)lauramide

Refernces

• 1、 Zhang, Yan,You, Qing,Fu, Yang,Zhao, Mingwei,Fan, Hongfu,Liu, Yifei,Dai, Caili. "Investigation on interfacial/surface properties of bio-based surfactant N-aliphatic amide-N,N-diethoxypropylsulfonate sodium as an oil displacement agent regenerated from waste cooking oil". . p. 68 - 74. Retrieved 2016.
• 2、 Kumar, Dinesh,Kim, Soo Min,Ali, Amjad. "Solvent-free one step aminolysis and alcoholysis of low-quality triglycerides using sodium modified CaO nanoparticles as a solid catalyst". . p. 55800 - 55808. Retrieved 2016/07/06.