2,3-Dimethylmorpholine

Base Information

• Chemical Name: 2,3-Dimethylmorpholine
• CAS No.: 52047-12-8
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.175
• European Community (EC) Number: 820-186-4
• Mol file: 52047-12-8.mol

Synonyms:2,3-dimethylmorpholine;52047-12-8;2,3-Dimethyl-morpholine;SCHEMBL4777950;MFCD18250305;AKOS006346794;AB72725;AS-47162;DB-191953;EN300-76285;F12405;F8880-7124;Z1187835063

Chemical Property of 2,3-Dimethylmorpholine

Chemical Property:

• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 115.099714038
• Heavy Atom Count: 8
• Complexity: 74.9

Purity/Quality:

99% ^*data from raw suppliers

2,3-dimethylmorpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1C(OCCN1)C

Technology Process of 2,3-Dimethylmorpholine

There total 2 articles about 2,3-Dimethylmorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

C6H11NO2 → (2R,3S)-2,3-dimethylmorpholine (52047-12-8,62302-32-3,62302-33-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

DOI:10.1055/s-0034-1379641

Reference yield:

C6H12ClNO2 → (2R,3S)-2,3-dimethylmorpholine (52047-12-8,62302-32-3,62302-33-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / dichloromethane; isopropyl alcohol / 1 h / 0 - 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 - 20 °C

With lithium aluminium tetrahydride; potassium tert-butylate; In tetrahydrofuran; dichloromethane; isopropyl alcohol;

DOI:10.1055/s-0034-1379641

Reference yield:

2,3-dimethylmorpholine (52047-12-8) + 4-bromomethylphenylboronic acid pinacol ester (138500-85-3) → 2,3-dimethyl-4-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl]morpholine

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 22h; Inert atmosphere;

Downstream raw materials:

5,8-bis-(2,3-dimethyl-morpholin-4-yl)-2-phenyl-pyrimido[4,5-d]pyridazine

Refernces