Synthesis (2014)
Update date:2022-08-05
Topics:
Dugar, Sundeep
Sharma, Amit
Kuila, Bilash
Mahajan, Dinesh
Dwivedi, Sandeep
Tripathi, Vinayak
A simple and efficient method has been developed for the synthesis of substituted morpholines by a sequence of coupling, cyclization, and reduction reactions of easily available amino alcohols and α-halo acid chlorides. Various mono-, di-, and trisubstituted morpholines, spiro morpholines, and ring-fused morpholines, as well as morpholine homologues, were synthesized in good to excellent yields by a single methodology under similar reaction conditions. The method was also used in a multigram synthesis of (3S)-3-methylmorpholine.
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