tert-butyl [(2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-1-(2-oxopropyl)piperidin-3-yl]carbamate

Base Information

Chemical Name:tert-butyl [(2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-1-(2-oxopropyl)piperidin-3-yl]carbamate
CAS No.:1280211-05-3
Molecular Formula:C₂₅H₃₃F₂N₅O₅S
Molecular Weight:553.63
Hs Code.:

Synonyms:tert-butyl [(2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-1-(2-oxopropyl)piperidin-3-yl]carbamate

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Chemical Property of tert-butyl [(2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-1-(2-oxopropyl)piperidin-3-yl]carbamate

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Technology Process of tert-butyl [(2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-1-(2-oxopropyl)piperidin-3-yl]carbamate

There total 9 articles about tert-butyl [(2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-1-(2-oxopropyl)piperidin-3-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1280210-88-9
tert-butyl {(2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]piperidin-3-yl}carbamate

: 78-95-5
chloroacetone

: 1280211-05-3
tert-butyl [(2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-1-(2-oxopropyl)piperidin-3-yl]carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; sodium iodide; In acetonitrile; for 168h;

Reference yield:

: 2646-90-4
2,5-difluorobenzaldehyde

: 1280211-05-3
tert-butyl [(2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-1-(2-oxopropyl)piperidin-3-yl]carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium acetate / ethanol / 16 h / Reflux

2.1: sodium tetrahydroborate / nickel (II) chloride hexahydrate / methanol / 1 h / 0 °C

2.2: 15 h / 0 - 20 °C

3.1: N,N,N,N,-tetramethylethylenediamine; trimethylsilyl iodide / dichloromethane / 2 h / 0 °C

3.2: 3 h

3.3: 0.17 h

4.1: N,N,N,N,-tetramethylethylenediamine / dichloromethane; N,N-dimethyl-formamide / 64 h / 20 °C

5.1: dimethylsulfide borane complex / tetrahydrofuran / 1.25 h / 70 °C

5.2: 0.75 h / 0 °C

6.1: N-ethyl-N,N-diisopropylamine / sodium iodide / acetonitrile / 168 h

With sodium tetrahydroborate; trimethylsilyl iodide; N,N,N,N,-tetramethylethylenediamine; dimethylsulfide borane complex; ammonium acetate; N-ethyl-N,N-diisopropylamine; nickel (II) chloride hexahydrate; sodium iodide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1280210-79-8,657428-42-7
2,6-dihydropyrrole [3,4-c]pyrazole-5(4H)-carboxylic acid tert-butyl ester

: 1280211-05-3
tert-butyl [(2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-1-(2-oxopropyl)piperidin-3-yl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.33 h / -40 - -30 °C

1.2: 1.5 h / -40 - -30 °C

1.3: 48 h / 0 - 20 °C

2.1: Isopropyl acetate / 18 h / 20 - 40 °C

3.1: N,N,N,N,-tetramethylethylenediamine / dichloromethane; N,N-dimethyl-formamide / 64 h / 20 °C

4.1: dimethylsulfide borane complex / tetrahydrofuran / 1.25 h / 70 °C

4.2: 0.75 h / 0 °C

5.1: N-ethyl-N,N-diisopropylamine / sodium iodide / acetonitrile / 168 h

With N,N,N,N,-tetramethylethylenediamine; dimethylsulfide borane complex; sodium hexamethyldisilazane; N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; dichloromethane; Isopropyl acetate; N,N-dimethyl-formamide; acetonitrile;