tert-butyl {(2R,3S,5R)-2-(2,5-difiuorophenyl)-1-(2,2-difluoropropyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]piperidin-3-yl}carbamate bis(trifluoroacetic acid salt)

Base Information

Chemical Name:tert-butyl {(2R,3S,5R)-2-(2,5-difiuorophenyl)-1-(2,2-difluoropropyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]piperidin-3-yl}carbamate bis(trifluoroacetic acid salt)
CAS No.:1280211-06-4
Molecular Formula:C₂₅H₃₃F₄N₅O₄S
Molecular Weight:575.628
Hs Code.:

tert-butyl {(2R,3S,5R)-2-(2,5-difiuorophenyl)-1-(2,2-difluoropropyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]piperidin-3-yl}carbamate bis(trifluoroacetic acid salt)

Synonyms:tert-butyl {(2R,3S,5R)-2-(2,5-difiuorophenyl)-1-(2,2-difluoropropyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]piperidin-3-yl}carbamate bis(trifluoroacetic acid salt)

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Chemical Property of tert-butyl {(2R,3S,5R)-2-(2,5-difiuorophenyl)-1-(2,2-difluoropropyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]piperidin-3-yl}carbamate bis(trifluoroacetic acid salt)

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Technology Process of tert-butyl {(2R,3S,5R)-2-(2,5-difiuorophenyl)-1-(2,2-difluoropropyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]piperidin-3-yl}carbamate bis(trifluoroacetic acid salt)

There total 10 articles about tert-butyl {(2R,3S,5R)-2-(2,5-difiuorophenyl)-1-(2,2-difluoropropyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]piperidin-3-yl}carbamate bis(trifluoroacetic acid salt) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1280211-05-3
tert-butyl [(2R,3S,5R)-2-(2,5-difiuorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-1-(2-oxopropyl)piperidin-3-yl]carbamate

: 1280211-06-4
tert-butyl {(2R,3S,5R)-2-(2,5-difiuorophenyl)-1-(2,2-difluoropropyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]piperidin-3-yl}carbamate bis(trifluoroacetic acid salt)

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at -78 - 20 ℃; for 3h;

Reference yield:

: 2646-90-4
2,5-difluorobenzaldehyde

: 1280211-06-4
tert-butyl {(2R,3S,5R)-2-(2,5-difiuorophenyl)-1-(2,2-difluoropropyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]piperidin-3-yl}carbamate bis(trifluoroacetic acid salt)

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonium acetate / ethanol / 16 h / Reflux

2.1: sodium tetrahydroborate / nickel (II) chloride hexahydrate / methanol / 1 h / 0 °C

2.2: 15 h / 0 - 20 °C

3.1: N,N,N,N,-tetramethylethylenediamine; trimethylsilyl iodide / dichloromethane / 2 h / 0 °C

3.2: 3 h

3.3: 0.17 h

4.1: N,N,N,N,-tetramethylethylenediamine / dichloromethane; N,N-dimethyl-formamide / 64 h / 20 °C

5.1: dimethylsulfide borane complex / tetrahydrofuran / 1.25 h / 70 °C

5.2: 0.75 h / 0 °C

6.1: N-ethyl-N,N-diisopropylamine / sodium iodide / acetonitrile / 168 h

7.1: diethylamino-sulfur trifluoride / dichloromethane / 3 h / -78 - 20 °C

With sodium tetrahydroborate; trimethylsilyl iodide; N,N,N,N,-tetramethylethylenediamine; diethylamino-sulfur trifluoride; dimethylsulfide borane complex; ammonium acetate; N-ethyl-N,N-diisopropylamine; nickel (II) chloride hexahydrate; sodium iodide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1280210-79-8,657428-42-7
2,6-dihydropyrrole [3,4-c]pyrazole-5(4H)-carboxylic acid tert-butyl ester

: 1280211-06-4
tert-butyl {(2R,3S,5R)-2-(2,5-difiuorophenyl)-1-(2,2-difluoropropyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]piperidin-3-yl}carbamate bis(trifluoroacetic acid salt)

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 1.33 h / -40 - -30 °C

1.2: 1.5 h / -40 - -30 °C

1.3: 48 h / 0 - 20 °C

2.1: Isopropyl acetate / 18 h / 20 - 40 °C

3.1: N,N,N,N,-tetramethylethylenediamine / dichloromethane; N,N-dimethyl-formamide / 64 h / 20 °C

4.1: dimethylsulfide borane complex / tetrahydrofuran / 1.25 h / 70 °C

4.2: 0.75 h / 0 °C

5.1: N-ethyl-N,N-diisopropylamine / sodium iodide / acetonitrile / 168 h

6.1: diethylamino-sulfur trifluoride / dichloromethane / 3 h / -78 - 20 °C

With N,N,N,N,-tetramethylethylenediamine; diethylamino-sulfur trifluoride; dimethylsulfide borane complex; sodium hexamethyldisilazane; N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; dichloromethane; Isopropyl acetate; N,N-dimethyl-formamide; acetonitrile;